Michael W. Kilgore, Ph.D.
Associate Professor
Health Sciences Center, Texas Tech University, 1990
Office: MN-354 Chandler Medical Center (0298)
Lab: MN-344; (859) 323-2604
Tel: (859) 323-1821
The Kilgore Lab Website
Current Projects
Recent advances in our understanding of gene regulation and function and the decoding of the human genome have presented those of us in medical research with a breathtaking opportunity to study the causes and cures of devastating disease such as cancer. My lab is focused on using these tools to address the cause of the rising rates of breast cancer and to examine the role of endogenous hormones such as the estrogens and environmental exposure in its etiology. These studies include the use a molecular approach to study hormone action and define dietary compounds that alter the risks of breast and other types of cancer. Recent findings in our lab demonstrate that like the estrogen receptor, the gamma form of the peroxisome proliferator-activated receptor (PPAR) may represent a therapeutic target for the prevention or treatment of several types of cancer including breast, prostate and lung cancer. We are using state-of-the art approaches including genechip technology, real-time PCR and other molecular tools to asses both basic mechanisms of hormone action and explore possible therapeutic approaches in the treatment of these tumors. Furthermore, we have now shown that like other hormones, fatty acids too bind receptor and mediate target gene expression which may represent a molecular link between diet and cancer including breast cancer.
Selected Publications (a complete publication list can be found at Dr. Kilgore's Website)
The PPARgamma antagonist T0070907 suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.
Zaytseva YY, Wallis NK, Southard RC, Kilgore MW.
Anticancer Res. 2011 Mar;31(3):813-23.
PMID: 21498701
Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner.
Al-Alem L, Southard RC, Kilgore MW, Curry TE.
PLoS One. 2011 Jan 21;6(1):e16179.
PMID: 21283708
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons.
Pancani T, Phelps JT, Searcy JL, Kilgore MW, Chen KC, Porter NM, Thibault O.
J Neurochem. 2009 Jun;109(6):1800-11. Epub 2009 May 11.
PMID: 19453298
Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.
Zaytseva YY, Wang X, Southard RC, Wallis NK, Kilgore MW.
Mol Cancer. 2008 Dec 5;7:90.
PMID: 19061500
PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells.
Allred CD, Talbert DR, Southard RC, Wang X, Kilgore MW.
J Nutr. 2008 Feb;138(2):250-6.
PMID: 18203887
PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis.
Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B.
Cardiovasc Toxicol. 2007;7(4):264-72. Epub 2007 Oct 23.
PMID: 17955387
MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells.
Wang X, Southard RC, Allred CD, Talbert DR, Wilson ME, Kilgore MW.
Breast Cancer Res Treat. 2008 Sep;111(1):103-11. Epub 2007 Sep 28.
PMID: 17902047
Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells.
Talbert DR, Allred CD, Zaytseva YY, Kilgore MW.
Breast Cancer Res Treat. 2008 Mar;108(1):23-33. Epub 2007 Apr 24.
PMID: 17453334
Selective activation of PPARgamma in breast, colon, and lung cancer cell lines.
Allred CD, Kilgore MW.
Mol Cell Endocrinol. 2005 May 12;235(1-2):21-9. Epub 2005 Mar 16.
PMID: 15866424
The increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usage.
Wang X, Southard RC, Kilgore MW.
Cancer Res. 2004 Aug 15;64(16):5592-6.
PMID: 15313896
Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells.
Wang X, Kilgore MW.
Mol Cell Endocrinol. 2002 Aug 30;194(1-2):123-33.
PMID: 12242035
Oxa-enediynes: probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization.
Jones GB, Wright JM, Hynd G, Wyatt JK, Warner PM, Huber RS, Li A, Kilgore MW, Sticca RP, Pollenz RS.
J Org Chem. 2002 Aug 9;67(16):5727-32.
PMID: 12153275
Target-directed enediynes: designed estramycins.
Jones GB, Hynd G, Wright JM, Purohit A, Plourde GW 2nd, Huber RS, Mathews JE, Li A, Kilgore MW, Bubley GJ, Yancisin M, Brown MA.
J Org Chem. 2001 Jun 1;66(11):3688-95.
PMID: 11374986
Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells.
Thoennes SR, Tate PL, Price TM, Kilgore MW.
Mol Cell Endocrinol. 2000 Feb 25;160(1-2):67-73.
PMID: 10715540
MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response.
Kilgore MW, Tate PL, Rai S, Sengoku E, Price TM.
Mol Cell Endocrinol. 1997 May 16;129(2):229-35.
PMID: 9202406
Additional Publications linked at NCBI's PubMed
Warning Some websites linked on this page for the convenience of users are not managed by the University of Kentucky. The university does not review, control or take responsibility for the contents of those sites.
Disclaimer: Journal articles can be downloaded from this site for personal use only and may not be duplicated or distributed for commercial reasons, without written authorization from the Journal, the copyright holder.