Guo-Min Li, Ph.D.
Associate Professor

125 Health Sciences Research Building
Graduate Center for Toxicology
University of Kentucky College of Medicine
1095 V.A. Drive
Lexington, KY 40536
Tel: (859)-257-7053
Fax: (859)-323-2094
e-mail: gmli@uky.edu

Academic Appointments:

• Graduate Center for Nutritional Sciences
• Graduate Center for Toxicology, College of Medicine
• Department of Molecular and Cellular Biochemistry, College of Medicine
• Department of Pathology and Laboratory Medicine, College of Medicine

Education:

• B.S., Biology, Wuhan University, China
• Ph.D., Chemistry, Wayne State University
• Postdoctoral Fellow, Duke University

Awards:

• James-Gardner Endowed Chair in Cancer Research

Research:

Molecular mechanism of DNA repair: DNA mismatch repair maintains genomic stability by correcting mismatches generated during normal DNA metabolism and by mediating DNA damage-induced apoptosis. Defects in mismatch repair genes are the genetic basis of certain types of human cancer, including hereditary nonpolyposis colorectal cancer. To fully understand the molecular mechanisms of the mismatch repair system in human cells, our work is focused on three areas: 1) Dissection and reconstitution of the human DNA mismatch repair reaction; 2) identification and characterization of proteins involved in DNA damage-induced, mismatch repair-dependent apoptosis; and 3) genetic alterations of mismatch repair genes in human cancer and other diseases.