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Geza Bruckner, Ph.D.
Professor

Department of Clinical Sciences/Clinical Nutrition
College of Health Sciences CTW
900 S. Limestone
University of Kentucky
Lexington, KY 40536-0200
Tel: (859)-3231100 ext 80859
Fax: (859)-323-6003
email: gbruckn@uky.edu

Academic Appointments:

• Professor Clinical Nutrition, University of Kentucky
• Professor Center for Toxicology, University of Kentucky
• Professor Nutritional Sciences, University of Kentucky

Education:

• University of Kentucky, Botany B.S.
• University of Kentucky, Animal Sciences Nutrition M.S.
• University of Kentucky, Nutrition & Toxicology Ph.D.
• Cornell University, Nutrition Postdoctorate

Awards:

• Oswald Scholarship for Creative Research
• UK Faculty Enrichment Grant
• Gnotobiotic Association Research Awards, Vth International Symposium,
• Elected Kentucky Chapter Alpha Eta Allied Health Honorary Society
• Honorary Faculty of Science and Technology, University of Wolverhampton,    England
• Kingston Award for Excellence in Teaching

Specific Interest in Nutrition:

Student education in nutritional sciences with emphasis on clinical nutrition and wellness and sports nutrition.

Research:

Most of the work in Dr. Bruckner’s laboratory for the last 25 years has been focused on lipid metabolism and cardiovascular function and disease. Of particular interest has been the metabolism of trans fatty acids and omega 3 fatty acids. Of interest has been how these dietary fatty acids influence lipoprotein metabolism, platelet-endothelial cell interactions, microcirculatory blood flow and more recently the antioxidant status of the host. Other areas of research interest have been Gnotobiology (study of germfree animals), where the research has focused on the interactions of the gut microflora with fatty acid metabolism and subsequent alteration of bioactive lipids. Current research has been aimed at: 1) defining the etiology of feline hepatic lipidosis. Feline hepatic lipidosis (FHL) is a well-recognized hepatopathy that is characterized by extensive lipid accumulation and diabetes mellitus and acute pancreatitis appear to contribute to the pathogenesis of FHL. Our findings show that a lack of n3 LPUFA in the diet during weight gain may predispose the feline to liver lipidosis, which is exacerbated by a weight reducing diet limited in n3 LPUFA. Based on the decreased number of mitochondria and peroxisomes, the primary mechanism involved in the pathogenesis appears to be decreased fatty acid oxidation; 2) elucidating the mechanisms by which phytoestrogens alter sperm function and reproductive capacity; 3) integration of complementary and alternative medicine (CAM) practices into the medical and health sciences curriculum and evaluating the acceptance of these practices by more traditional western health care professionals; and 4) reducing obesity and sedentary behaviors in highly structured environments and how alteration of these health risk factors may impact on worksite safety.

Publications (Selected/Representative):

1. Bruckner, G. , l972. The effect of reduced oxygen partial pressure in inhaled air on the release of bioactive substances in human saliva. Archs. Oral. Biol. l7:465-472.

2. Bruckner, G.G. , l973. Epinephrine inhibitory substance in intestinal contents of germfree rats, in "Germfree Research", pp. 535-54l, Academic Press, Inc., New York.

3. Baez, G., G.G. Bruckner and H.A. Gordon, l973. Responsiveness of jejunal-ileal mesentery microvessels in unoperated and cecectomized germfree rats to some smooth muscle agonists, in "Germfree Research", pp. 527-53l, Academic Press, Inc., New York.

4. Baez, S., G. Bruckner, Y.P. Waldemar, O.P. Miniats and H.A. Gordon, l978. Vascular smooth muscle depressant substances in germfree piglets, in "Clionical and Experimental Gnotobiotics" (T. Fliedner, H. Heit, D. Niethammer and H. Pflieger, eds.) pp. l29-l33. Proc. VIth International Sym. on Gnotobiology, Ulm, Germany. G. Fisher, Stuttgart and New York.

5. Gordon, H.A., Rovin, S. and Bruckner, G., l978. Blood flow, collagen components of oral tissue and salivary kallikrein in young to senescent, germfree and conventional rats. Gerontology 24:l-ll.

6. Kinsella, J.E., G. Bruckner, J. Mai, and J. Shimp, l98l. Metabolism of trans fatty acids with emphasis on the effects of trans, trans octadecadienoate on prostaglandin biosynthesis and organ lipid composition: An overview. Am. J. Clin. Nutr. 34:230l-23l8.

7. Bruckner, G. , J. Shimp, S.K. Goswami, J. Mai, and J.E. Kinsella, l982. Dietary trilinoelaidate: Effects on metabolic parameters related to EFA metabolism in the rat. J. Nutr. ll2:l26-l35.

8. Shimp, J., G. Bruckner and J.E. Kinsella, l982. The effects of dietary trilinoelaidin on fatty acid composition and acyl desaturase in rat liver. J. Nutr. ll2:722-735.

9. Grunewald, K., G.E. Mitchell, Jr., R.E. Tucker, B. Langlois and G. Bruckner, l982. Influence of bilateral nephrectomy on selected gastrointestinal bacteria. Can. J. Physiol. and Pharm. 60:664-669.

10. Bruckner, G. , S. Trimbo, S.K. Goswami and J.E. Kinsella, l983. Dietary trilinoelaidate: Effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. J. Nutr. ll3:704-7l3.

11. Bruckner, G. , J. Infante, G.F. Combs, Jr. and J.E. Kinsella, l983. Effects of vitamin E and aspirin on the incidence of encephalomalacia, fatty acid status and serum thromboxane levels in chicks. J. Nutr. ll3:l885-l890.

12. Bruckner, G. , S. Goswami, and J.E. Kinsella, l984. Dietary trilinoelaidate: Effects on organ fatty acid composition, prostanoid biosynthesis and platelet function in rats. J. Nutrition, Vol. ll4, No. l, p. 58-67.

13. Bruckner, G. , R.E. Tucker, K. Grunewald and G.E. Mitchell, Jr., l984. Essential fatty acid status and characteristics associated with colostrum deprived gnotobiotic and conventional lambs. Growth, organ development, cell membrane integrity and parameters associated with lower bowel function. J. Animal Sci., Vol. 58, No. 4:97l.

14. Bruckner, G. , B. Lokesh, B. German and J.E. Kinsella, l984. Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. Thrombosis Research 34:479-497.

15. Gordon, H.A., and G. Bruckner, l984. Anomalous lower bowel function and related phenomenon in germfree animals. Chapter in: The Germfree Animal in Biomedical Research (eds. Coates and Gustaffson), Laboratory Animals Ltd., pp. l93-2l3.

16. Bruckner, G. , R.E. Tucker, K.K. Grunewald and G.E. Mitchell, Jr., l984. Essential fatty acid status of colostrum-deprived gnotobiotic and conventional lambs: Organ fatty acid composition. Nutr. Res. 4:503-508.

17. Bruckner, G. and J. Szabo, l984. Nutrient absorption in gnotobiotic animals. Chapter in: Advances in Nutrition Research, Vol. 6, H.H. Draper, ed., Plenum Press, p. 27l-332.

18. German, J.B., G.G. Bruckner, B. Lokesh and J.E. Kinsella, l985. Effect of increasing levels of fish oil on tissue lipids and prostaglandin. Nutr. Res. 5:5ll-520.

19. Bruckner, G. , P. Webb, L. Greenwell, C. Chow and D. Richardson, l987. Fish oil increases peripheral capillary blood cell velocity in humans. Atherosclerosis 6:237-248.

20. Bruckner, G. , l987. Fats and the microflora: An overview. Microecology & Therapy, Vol. l7, 9l-95.

21. Bond, Vernon, Jr., O. Order, G. Bruckner, P. Webb and T. Kotchen, l989. Effects of fish oil or fiber supplement on blood pressure and lipid metabolism in the DOCA-salt hypertensive rat. J. Nutrition, Vol. ll9, No. 5, p. 813-820.

22. Bruckner, G. , 1991. Omega-3 Fatty Acids and Microcirculation. In: Fish Oil and Blood Vessel Wall Interactions (P.M. Vanhoutte and P.H. Douste-Blazy eds.), John Libby Eurotext, p. 99-109.

23. Russell, J. and G. Bruckner, l991. Microbial Ecology of the Normal Animal Intestinal Tract, Chapter in: World Animal Science, (J.B. Woolcock, ed.)., Vol. B7, p. 1.

24. Ware, S.K., Bruckner, G., Atakkaan, A., Giles, T., Webb, P., Chow, C. and Richardson, D, 1992. Omega-3 fatty acids, vitamin E and cutaneous blood flow in healthy elderly male subjects. Nutrition, Metabolism and Cardiovascular Disease, 2:33-39.

25. Bond, Veron, G. Bruckner, P. Webb, T. Kotchen, R.J. Tearney and R.G. Adams, 1992. Effects of dietary fish oil and exercise training on blood pressure in DOCA-salt hypertensive rats. Med. Sci. Res., 20:485-487.

26. Szabo, J., E. Fodor, L. Koranyi and G. Bruckner. Effect of nutrients on plasma corticosterone concentration in cold-stressed rats. Ann. Nutrition and Metabolism, 1993: 37:53-61.

27. Szabo, J., G. Bruckner. 1995 ATP "Potential" of nutrients may regulate plasma corticosteroid concentration: a hypothesis. J. Nutr. Biochem., 6:12-20.

28. Szabo, J., E. Kosa, I.E. Toth, and G. Bruckner. 1995. Effect of adenosine and its metabolites on the hypothalamo-pituitary-adrenal axis. J. Nutr. Biochem., 6:334-339.

29. Toth, I., D. Szabo and G. Bruckner. 1997. Lipoproteins, Lipid Droplets, Lysosomes, and Adrenocortical Steroid Hormone Synthesis: Morphological Studies. Microscopy Research and Technique 36:480-492

30. Wissam, I., U. Lee, C. Yeh, J. Szabo, G. Bruckner and C. Chow. 1997. Oxidative Stress in Mouse Liver: Effects of Dietary lipid, Vitamin E and Iron. J. Nutr. 127:21-27.

31. Bruckner, G., 2000.Fatty acids and Cardiovascular Diseases. Chapter In: Fatty Acids in Foods and Their Health Implications, Second Edition (C.K. Chow, ed.), Marcel Dekker Inc., p.843-864

32. Bruckner, G., 2000. Fatty Acids, Lipids and Cellular Signaling. Chapter In: Fatty Acids in Foods and Their Health Implications, Second Edition (C.K. Chow, ed.), Marcel Dekker Inc., p. 607-618

33. Szabo, J., G. Bruckner, I. Medveczky, E. Kosa and A. Balogh. 1999. Ethanol’s Effect on Rat Pituitary Adrenal Axis is Prevented by Purine Metabolic Pathway Inhibitors. Proc. Soc. Exp. Biol. Med. 220(2):112-118.

34. Ibrahim, W., Lee, U.-S., Szabo, J., Bruckner, G., Chow, C.K. 1999 Oxidative stress and antioxidant status in mouse kidney: effects of dietary lipid and vitamin E plus iron. J. Nutr. Biochem. 10: 674-678

35. Szabo, J., W. Ibrahim, K. Dickey, J. Rodgers, I. Toth, G. Boissonneault, G.D. Sunvold and G. Bruckner. 2000. Influence of dietary protein and lipid on weight loss in obese ovariohysterectomized female cats. Am J Vet Res. 61:559-565

36. Ibrahim, W., J. Szabo, G.D. Sunvold, J. Kelleher and G. Bruckner. 2000. The effect of dietary protein quality and essential fatty acids on serum lipoprotein concentrations and liver triglyceride fatty acid synthesis in obese cats undergoing rapid weight loss. Am J Vet Res. 61:566-572

37. Barta, Z., Szabo G.G,, Bruckner G., and Szegedi G. 2001 Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD). Med. Sci. Monit. 7(1):134-136

38. Maynard LM., GA. Boissonneault, CK. Chow and G. Bruckner. 2001 High levels of dietary carnosine are associated with increased concentrations of carnosine and histidine in rat soleus muscle. J. Nutr. 131: 287-290.

39. Widanski, B., D. Richardson and G. Bruckner. 2002 The effect of urate on nitric oxide microcirculatory response in the rat tail to body heating. Microcirculation 9:125-131

40. Lenn, J., T. Uhl, C. Mattacola, G. Boissonneault, J. Yates, W. Ibrahim, G. Bruckner. 2002The effects of fish oil and isoflavones on delayed onset muscle soreness. Medicine and Science in Sports and Exercise 34: 1605-1613.

41. Szabo, J., W. Ibrahim, G.D. Sunvold and G. Bruckner. Dietary protein quality and essential fatty acid effects on liver and adipose tissue fatty acid composition following rapid weight loss in obese cats. Am J Vet Res. 2003 Mar;64(3):310-155

42. Ibrahim, W., Bailey, N., Sunvold G.D., and G.Bruckner 2003 Fatty acid metabolism and liver lipid accumulation in cats during weight gain and weight loss: Effects of carnitine and taurine Am J Vet Res. Oct;64(10):1265-77.

43. Sipka S, Kovacs I, Szanto S, Szegedi G, Brugos L, Bruckner G, Szentmiklosi J. 2005 Adenosine inhibits the release of interleukin-1beta in activated human peripheral mononuclear cells. Cytokine. 2005 Aug 21;31(4):258-63

Publications in Press

Cervantes-Laurean D, Schramm DD, Jacobson E, Halaweish I, Bruckner G, Boissonneault G. 2005 Inhibition of Advanced Glycation End Product Formation on Collagen by Rutin and its Metabolites. J. Nutr. Biochem.