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Mechanical ventilation is one of the most common
interventions used to support critically ill patients. Up to
one third of ventilated patients have difficulty
establishing and maintaining independent spontaneous
ventilation after a period of mechanical ventilation.
Mechanical ventilation produces inflammation, and
inflammatory mediators are associated with cardiovascular
dysfunction. Because cardiovascular instability is one
mechanism that produces weaning failure, the effect of
inflammation on cardiovascular function and subsequent
weaning ability in ventilated patients requires study. The
purpose of this study is to evaluate the effects of
inflammation and cardiovascular function on ventilator
weaning outcome.
This study will use a predictive correlational design and
non-probability sample of 60 ventilated medical intensive
care patients. Data will be collected on study entry as the
patient receives mechanical ventilation and during the
initial weaning trial. Demographic and clinical status data
will be captured and inflammatory biomarkers and
cardiovascular function will be measured at the 2 time
points. Repeated measures ANOVA will determine whether
cardiovascular variables or inflammatory biomarkers differ
by group (weaning success and failure) and across time
(baseline and at end of weaning trial). Correlation
coefficients will evaluate the association between cardiac
function and inflammatory biomarkers. Logistic regression
will evaluate the predictive power of inflammatory
biomarkers and cardiovascular function for weaning success.
This investigation will provide information about the role
of inflammation and cardiovascular function in the ability
to wean from mechanical ventilation.
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