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Clinical and Translational Research

Clinical research happens throughout our college, potentially wherever a dental care provider and patient interact. 

Study volunteers are always needed and some projects may reimburse subjects for time and travel or defray the cost of dental care.  Below are our current clinical projects, please contact study personnel for more details.

Xenogenic Collagen Matrix to Increase the Zone of Attached Mucosa Around Implant

Principle Investigator:  Mohanad Al-Sabbagh, College of Dentistry
Sponsor:  Luitpold Pharmaceuticals, Inc.
The objective of this clinical prospective split-mouth study is to evaluate the efficacy of Collagen Matrix as an alternative to the Epithelialized free graft to aesthetic outcomes, patient morbidity, and the safety of using CM will be assessed and compared to the free gingival graft (FGG).

For more information contact:  Cheryl Huffman, cehuff0@uky.edu

Chronic Inflammation at Oral and Cervico-Vaginal Mucosa

Principle Investigator:  Kristin Ashford, BSN, MSN, College of Nursing
Sponsor:  National Institutes of Health (COBRE)
Preterm birth and low birthweight deliveries continue to increase in the U.S resulting in substantial economic and societal costs.  Adverse pregnancy outcomes are disproportionately expressed in ethnic and racial minority populations and historically underserved populations, particularly from rural regions of the nation.  To define the differences in the expression of trimester-specific prenatal inflammatory markers between women who do and do not experience preterm birth in a multi-racial/ethnic population.  

For more information contact:   Kristin Ashford, khashf0@uky.edu

Coordinated oral-intestinal immune responses in Inflammatory Bowel Diseases (IBD)

Principle Investigator:  Maria Bruno
Sponsor:  National Institutes of Health (COBRE)
Chronic inflammatory conditions in the oral cavity can be linked to dysregulated innate and adaptive immune responses to the oral commensal microbiota. Inflammatory Bowel Diseases, such as Crohn’s disease (CD) and ulcerative colitis (UC) are also thought to arise from an abnormal immune response to the gut microbiota in genetically susceptible individuals. Specific Aim 1: To identify genes which are coordinately regulated between the gingiva and the intestine from CD patients and healthy control individuals.  Specific Aim 2: To expand the number of disease biomarkers that can be useful to predict disease behavior and responses to therapy in CD and UC patients.
    
For more information contact:  Maria Bruno, mebrun2@uky.edu

Efficacy of iocide oral rinse in a human clinical trial of gingival inflammation and effects on biological markers indicated of systemic disease

Principle Investigator:  Dolph Dawson, DMD, MS College of Dentistry
Sponsor:  Biomedical Development Corporation
The purpose of this study is to explore the efficacy of Iocide oral rinse in a double-blind placebo-controlled human trial of gingivitis.  Plaque and bleeding will be scored and blood tests will be performed to determine the effect of the antimicrobial oral rinse on relative levels of biological markers of inflammation.

For more information Contact:  Hailey Gallivan, hbwils00@uky.edu

Genetic predisposition to dysregulated chronic inflammation

Principle Investigator:  Lorri Morford, College of Dentistry
Sponsor:  National Institutes of Health (COBRE)
The purpose of this study is to define a general pattern of genetic predisposition to CI that could be used clinically to identify patients at heightened risk of CID development prior to the onset of permanent and/or debilitating tissue damage.   

For more information contact:  Lorri Morford, lorri.moford@uky.edu

Gene-environment interactions reg CVD infl/success of behavioral therapies

Principle Investigator:  Gia Mudd, MPH, College of Nursing
Sponsor:  National Institutes of Health (COBRE)
The overall goal of this study is to examine the relationship between inflammatory genotype and the effects of a cardiovascular risk-reduction intervention on systemic inflammation.  Data on CVD risk factors including blood pressure, lipid profile, diabetes, smoking and other lifestyle factors is being collected at baseline and immediate and extended post-intervention.

For more information contact:  Gia Mudd, gia.mudd@uky.edu