COBRE Progress and Opportunitites

Selected COBRE Publications


  1. Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, Wei J, Daugherty A, Smart EJ*, Reid MB, Merrill AH Jr and Nikolova-Karakashian M. Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. J Biol Chem. 2009 Mar 27;284(13):8359-68. PMID: 19074137

  2. Guo L, Song Z, Li M, Wu Q, Wang D, Feng H, Bernard P, Daugherty A, Huang B and Li XA*. Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. J Biol Chem. 2009 Jul 24;284(30):19826-34. PMID: 19491399

  3. Heron, PM; Turchan-Cholewo, J; Bruce-Keller, AJ and Wilson ME*. Estrogen receptor alpha inhibits the estrogen-mediated suppression of HIV transcription in astrocytes: implications for estrogen neuroprotection in HIV dementia. AIDS Research and Human Retroviruses. 2009 Nov;25(11):1071-81. PMID: 19886840

  4. Lee S, Kang DW, Hudgins-Spivey S, Krust A, Lee EY, Koo Y, Cheon Y, Gye MC, Chambon P and Ko C*. Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely. Endocrinology. 2009 Aug;150(8):3855-62. PMID: 19423761

  5. Li F and Curry TE Jr*. Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells. Endocrinology. 2009 Aug;150(8):3903-12. PMID: 19389837

  6. Li F, Liu J, Park ES, Jo M* and Curry TE Jr*. The B cell translocation gene (BTG) family in the rat ovary: hormonal induction, regulation, and impact on cell cycle kinetics. Endocrinology. 2009 Aug;150(8):3894-902. PMID: 19359386

  7. Li J, White J, Guo L, Zhao X, Wang J, Smart EJ* and Li XA*. Salt inactivates endothelial nitric oxide synthase in endothelial cells. J Nutr. 2009 Mar;139(3):447-51. PMID: 19176751

  8. Lile, JA*, Kelly, TH*; Pinsky, DJ and Hays, LR. Substitution profile of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating Delta9-tetrahydrocannabinol. Psychopharmacology (Berl). 2009 Apr;203(2):241-50. PMID: 19018520

  9. Pancani T, Phelps JT, Searcy JL, Kilgore MW*, Chen KC, Porter NM and Thibault O*. Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J Neurochem. 2009 Jun;109(6):1800-11. PMID: 19453298

  10. Wilson ME* and Westberry JM. Regulation of oestrogen receptor gene expression: new insights and novel mechanisms. J Neuroendocrinol. 2009 Mar;21(4):238-42. PMID: 19207817


  1. Adjan, VV; Centers, A and Jennes, L*. Expression and activation of N-methyl-D-aspartate receptor subunit-1 receptor subunits in gonadotropin-releasing hormone neurons of young and middle-aged mice during the luteinising surge. J. Neuroendocrinol. 2008 Oct;20(10):1147-54. PMID: 18673408

  2. Babalonis S; Emurian C; Martin CA*; Lile JA* and Kelly TH*. Modulation of the discriminative stimulus effects of triazolam across the menstrual cycle phase in healthy pre-menopausal women. Drug Alcohol Depend. 2008 Apr 1;94(1-3):276-80. PMID: 18178039

  3. Bridges PJ*, Koo Y, Kang DW, Hudgins-Spivey S, Lan ZJ, Xu X, DeMayo F, Cooney A and Ko C*. Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis. 2008 Sep;46(9):499-505. PMID: 18781648

  4. Joseph, JE*; Liu, X; Jiang, Y; Lynam, D and Kelly, TH*. Neural correlates of emotional reactivity in sensation seeking. Psychol Sci. 2009 Feb;20(2):215-23. PMID: 19222814

  5. Liu, X; Steinmetz, NA; Farley, AB; Smith, CD and Joseph, JE*. Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. J Cogn Neurosci. 2008 Sep;20(9):1711-26. PMID: 18345986

  6. Park ES, Choi S, Muse KN*, Curry TE Jr* and Jo M*. Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary. Endocrinology. 2008 Jun;149(6):3025-36. PMID: 18308847

  7. Wilson, ME*; Sengoku, T and Allred, KF. Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir. J Cell Biochem. 2008 Apr 1;103(5):1598-606. PMID: 17879945

  8. Wilson ME*; Westberry, JM and Prewitt, AK. Dynamic regulation of estrogen receptor-alpha gene expression in the brain: a role for promoter methylation? Front Neuroendocrinol. 2008 Jun;29(3):375-85. Epub 2008 Mar 13. PMID: 18439661


  1. Al-Alem, L; Bridges, PJ*; Su, W; Gong, MC; Iglarz, M and Ko, C*. Endothelin-2 induces oviductal contraction via endothelin receptor subtype A in rats. J Endocrinol. 2007 Jun;193(3):383-91. PMID: 17535876

  2. Allred, CD; Talbert,D; Southard, RC; Wang, X and Kilgore, MW*. PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. J Nutr. 2008 Feb;138(2):250-6. PMID: 18203887

  3. Gieske, MC; Kim, HJ; Legan, SJ; Koo, Y; Krust, A; Chambon, P and Ko, C*. Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females. Endocrinology. 2008 Jan;149(1):20-7. Epub 2007 Oct 18. PMID: 17947360

  4. Kim, HJ; Gieske, MC; Hudgins, S; Kim, BG; Krust, A; Chambon, P and Ko, C*. Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary. J Endocrinol. 2007 Dec;195(3):393-405. PMID: 18000302

  5. Lile JA*; Kendall SL; Babalonis S; Martin CA* and Kelly TH*. Evaluation of estradiol administration on the discriminative-stimulus and subject-rated effects of d-amphetamine in healthy pre-menopausal women. Pharmacol Biochem Behav. 2007 Jun-Jul;87(2):258-66. Epub 2007 May 5. PMID: 17544491

  6. Park, ES; Choi, S; Muse, KN*; Curry, TE Jr* and Jo, M*. Response gene to complement 32 expression is induced by the luteinizing hormone (LH) surge and regulated by LH-induced mediators in the rodent ovary. Endocrinology. 2008 Jun;149(6):3025-36. Epub 2008 Feb 28. PMID: 18308847

  7. Wang, X; Allred, CD; Talbert, D; Southard, RC; Wilson, ME* and Kilgore, MW*. MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells. Breast Cancer Res Treat. 2008 Sep;111(1):103-11. Epub 2007 Sep 28. PMID: 17902047

  8. Westberry, JM; Prewitt, AK and Wilson ME*. Epigenetic regulation of the estrogen receptor alpha promoter in the cerebral cortex following ischemia in male and female rats. Neuroscience. 2008 Apr 9;152(4):982-9. Epub 2008 Feb 8. PMID: 18353557

  9. Wilson ME*; Allred KF; Kordik EM; Jasper DK; Rosewell AN and Bisotti AJ. Gender-specific effects of HIV protease inhibitors on body mass in mice. AIDS Res Ther. 2007 May 1;4:8. PMID: 17472747


  1. Bradshaw EL, Li XA, Guerin T, Everson WV, Wilson ME, Bruce-Keller AJ,Greenberg RN, Guo L, Ross SA, Smart EJ. (2006) Nucleoside reverse transcriptase inhibitors prevent HIV proteaseinhibitor-induced atherosclerosis by ubiquitination and degradation of proteinkinase C. Am J Physiol Cell Physiol. 2006 Dec;291(6):C1271-8.

  2. Curry TE Jr and Smith MF. (2006) Impact of extracellular matrix remodeling on ovulation and the folliculo-lutealtransition. Semin Reprod Med. 2006 Sep;24(4):228-41. Review.

  3. Dimayuga FO, Wang C, Clark JM, Dimayuga ER, Dimayuga NM, Bruce-Keller AJ* (2007) SOD1 overexpression alters ROS production and reduces neurotoxic inflammatory signaling in microglial cells. J. Neuroimmunol. 182: 89-99.

  4. El-Hage N, Wu G, Wang J, Ambati J, Knapp PE, Reed JL, Bruce-Keller AJ*, Nath A, Hauser KF. (2006) HIV Tat1-72 and Opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia 53:132-46.

  5. Jo M and Curry TE Jr. (2006) Luteinizing hormone-induced RUNX1 regulates the expression of genes in granulosa cells of rat periovulatory follicles. Mol Endocrinol. 2006 Sep;20(9):2156-72.

  6. Joseph JE, Cerullo MA, Farley AB, Steinmetz NA, Mier CR. (2006) fMRI correlates of cortical specialization and generalization for letterprocessing. Neuroimage. 2006 Aug 15;32(2):806-20.

  7. Hauser KF, El-Hage N, Buch S, Nath A, Tyor WR, Bruce-Keller AJ*, Knapp PE. (2006) Impact of Opiate-HIV-1 Interactions on Neurotoxic Signaling. J. Neuroimmune Pharmacol (2006) 1:98-105.

  8. Prewitt AK and Wilson ME (2006) Changes in estrogen receptor-alpha mRNA in the mouse cortex during development. Brain Res 1134 1, 2007 Feb 23 pp.62-9.

  9. Smedts AM, Lele SM, Modesitt SC, Curry TE. (2006) Expression of an extracellular matrix metalloproteinase inducer (basigin) inthe human ovary and ovarian endometriosis. Fertil Steril. 2006 Sep;86(3):535-42.

  10. Stocker SD, Wilson ME, Madden CJ, Lone U, Sved AF. (2006) Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretionstimulated by hemorrhage and hypotension but not hyperosmolality in rats. Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R59-67.

  11. Turchan-Cholewo J*, Liu Y, Gartner S, Jie C, Peng X, Chu K, Chen C, Chauhan A, Haughey N, Cutler R, Mattson M, Pardo C, Conant K, Sacktor N, McArthur JC, Hauser KF, Gairola C, Nath A (2006) Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl. Neurobiology of Disease, 2006 Jul;23(1):109-19.

  12. Wilson, ME*, Dimayuga, FO, Reed, JL, Curry, TE*, Anderson, CF, Nath, A, Bruce-Keller, AJ*. (2006) Immune Modulation by Estrogens: Role in CNS HIV-1 Infection. Endocrine 29:289-298.


  1. Allred KF, Smart EJ, Wilson ME* (2005) Estrogen receptor-alpha mediates gender differences in atherosclerosisinduced by HIV protease inhibitors. J Biol Chem 281 1419-25 2006

  2. Apparsundaram S*, Martinez V, Parikh V, Kozak R, Sarter M (2005) Increased capacity and density of choline transporters situated in synaptic mambranes of the right medial prefrontal cortex of attention task-performing rats. J Neurosci 25 3851-3556 2005

  3. Crudden G, Chitti, R, Craven, R* (2005) Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs. J Pharmacol Exp Ther. 2006 Jan; 316(1):448-55.

  4. El-Hage N, Wu G, Wang J, Ambati J, Knapp PE, Reed JL, Bruce-Keller AJ*, Hauser KF (2005) HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis ofmicroglia through the expression of MCP-1 and alternative chemokines. Glia 53 132-46 2006

  5. Ferry Al, Locasto DM, Meszaros LB, Bailey JC, Jonsen M, Brodsky K, Hoon CJ, Gutierrez-Hartmann A, Diamond SE*. (2005) Pit-1 Beta Reduces Transcription and CBP Recruitment in a DNA Context Dependent Manner. Journal of Endocrinology, 185:173-185, 2005

  6. Gieske MC, Na, GY, Koo, Y, Jo M, Curry TE JR*, Ko, C (2005) Decay-accelerating factor in the periovulatory rat ovary. J Endocrinol 186 303-13 2005

  7. Hauser KF, El-Hage N, Buch S, Berger Jr, Tyor WR, Nath A*, Bruce-Keller AJ, Knapp PE. (2005) Molecular targets of opiate drug abuse in NeuroAIDS. Neurotoxicity Research, 8(1-2): 63-80, 2005

  8. Sporici RA, Hodskins JS, Locasto DM, Meszaros LB, Ferry AL, Weidner AM, Rinehart CA, Bailey JC, Mains IM, Diamond SE*. (2005) Repression of the prolactin promoter, a functional consequence of the heterodimerization between Pit-1 and Pit-1 beta, Journal of Molecular Endocrinology, 35:317-331, 2005

  9. Zhu W and Smart EJ* (2005) Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- andan AMP kinase-dependent manner. J Biol Chem 280 29543-50 2005


  1. Gathers AD, Bhatt R, Corbly CR, Farley AB, Joseph JE (2004) Developmental shifts in cortical loci for face and object recognition. NeuroReport 15(10):1549-1553.

  2. Jo M and Curry TE Jr. (2004) Regulation of matrix metalloproteinase-19 messenger RNA expression in the rat ovary. Biol Reprod 71(6):1796-1806.

  3. Makris AP, Rush CR, Frederich RC, Kelly TH (2004) Wake-promoting agents with different mechanisms of action: A comparison of the effects of amphetamine and modafinil on food intake and cardiovascular activity. Appetite, 42:185-195.

  4. Joseph JE, Farley AB (2004) Cortical regions associated with different aspects of performance in object recognition. Cogn Affect Behav Neurosci 4(3):364-378.

  5. Jo M, Gieske MC, Payne CE, Wheeler-Price SE, Gieske JB, Ignatius IV, Curry TE Jr, Ko C (2004) Development and application of a rat ovarian gene expression database (rOGED). Endocrinology 145(11):5384-5396.

  6. Martin CA, Kelly TH, Rayens MK, Brogli BR, Himelreich K, Brenzel A, Bingcang CM, Omar HA (2004) Sensation seeking and symptoms of disruptive disorder: Association with nicotine, alcohol, and marijuana use in early and mid-adolescents. Psychol Rep 94:1075-1082.

  7. Bailey J and Jennes L* (2004) Glutamatergic regulation of gonadotropin releasing hormone in the rodent. Recent Res Devel Endocrinol 4 1-12 2004

  8. Chikani G, Zhu W, Smart EJ* (2004) Lipids: potential regulators of nitric oxide generation. Am J Physio Endocrinol Metab 287 E386-E389 2004

  9. Eyigor O, Lin W, Jennes L* (2004) Localization of glutamatergic neurons that express estrogen receptor-a in the hypothalamus of the female rat. J Neuroendocrinol 16 26-31 2004

  10. Eyigor O, Lin W, Jennes L* (2004) Identification of neurons in the female rat hypothalamus that express estrogen receptor-alpha and vesicular glutamate transporter-2. J. Neuroendocrinol. 16:26-31 2004


  1. Jo M, Thomas LE, Wheeler SE, Curry Jr TE (2003) Membrane type-1-matrix metalloproteinase (MMP)-associated MMP-2 activation increases in the rat ovary in response to an ovulatory dose of human chorionic gonadotropin. Biol Reprod 70:1024-1032.

  2. Gong M, Wilson M, Kelly T, Su W, Dressman J, Kincer J, Matveev SV, Guo L, Guerin T, Li XA, Zhu W, Uittenbogaard A, Smart EJ (2003) HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J Clin Invest 111:1579-1587.

  3. Zhu W and Smart EJ (2003) Caveolae, estrogen and nitric oxide. Trends Endocrinol Metab 14(3):114-117.

  4. Dimayuga FO, Ding Z, Keller JN, Marchionni MA, Seroogy KB, Bruce-Keller AJ (2003) The neuregulin GGF2 attenuates free radical release from activated microglial cells. J Neuroimmunol 136(1-2):67-74.

  5. Lin W, McKinney K, Liu L, Lakhlani S, Jennes L (2003) Distribution of vesicular glutamate transporter-2 messenger ribonucleic acid and protein in the septum-hypothalamus of the rat. Endocrinology 144(2):662-670.

  6. Turchan J, Pocernich CB, Gairola C, Chauhan A, Schifitto G, Butterfield DA, Buch S, Narayan O, Sinai A, Geiger J, Berger JR, Elford H, Nath A (2003) Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology 60(2):307-314.

  7. Bruce-Keller, AJ*, Chauhan, A, Dimayuga, FO, Gee, J, Keller, JN, Nath, A (2003) Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. J Neurosci 23 8417-22 2003

  8. Kelly, TH*, Stoops, WW, Perry, AS, Prendergast, MA, Rush, CR (2003) Clinical Neuropharmacology of Drugs of Abuse: A Methodological Review. Behavioral and Cognitive Neuroscience Reviews 2:227-260 2003

  9. Komar, CM and Curry, TE Jr. (2003) Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. Biol.of Reprod. 69:549-555 2003

  10. Salvatore, MF, Apparsundarm, S*, Gerhardt, GA (2003) Decreased plasma membrane expression of striatal dopamine transporter in aging. Neurobiol Aging. 24(8):1147-54 2003.


  1. Wang X and Kilgore MW (2002) Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells. Mol Cell Endocrinol. 194(1-2):123-33.

  2. Curry TE Jr. and Wheeler SE (2002) Cellular localizaton of tissue inhibitors of metalloproteinases in the rat ovary throughout pseudopregnancy. Biol Reprod 67:1943-1951.

  3. Komar CM and Curry TE (2002) Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats. Biol Reprod 66:1531-1539.

  4. Li XA, Titlow WB, Jackson BA, Giltiay N, Nikolova-Karakashian M, Uittenbogaard A, Smart EJ (2002) High density lipoprotein binding to scavenger receptor, class b, type I activates endothelial nitric-oxide synthase in a ceraminde-dependent manner. Biol. Chem. 277(13)11058-11063.


  1. Komar CM, Braissant O, Wahli W, Curry Jr. TE (2001) Expression and localization of peroxisome proliferator-activated receptors in the rat ovary during follicular development and the periovulatory period. Endocrinology 142(11) 4831-4838.

  2. Graf AG, Roswell KL, Smart EJ (2001) 17β-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers. J Lipid Res. 42(9):1444-9.

  3. Bruce-Keller AJ, Barger SW, Moss NI, Pham JT, Keller JN, Nath A (2001) Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol. J Neurochem. 78(6):1315-24.

  4. Kelly TH, Fredenburg AM, Emurian CS, Martin CA, Hays LR, Rush CR (2001) Discriminative-stimulus effects of triazolam: Influence of menstrual cycle phase. Drug and Alcohol Dependence 63:S79.

  5. Makris AM, Kelly TH, Wilson J (2001) The effects of modafinil on food intake, verbal reports of drug effect, performance and cardiovascular activity in normal, healthy men and women. Drug and Alcohol Dependence 63:S96.



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