AAA PPG Core C

Personnel

Hong Lu, Ph.D.
Core Director

Deborah Howatt, B.S.

This Core will facilitate the measurements and characterization of vascular pathology and of plasma parameters that are critical to the interpretation of experimental studies. The quantification of these vascular pathologies requires trained personnel. Therefore, having experienced technical staff who provide accurate and reproducible analysis of tissues using a blinded study design will permit objective assessment for all studies. This centralization will be more efficient and enhance quality control. This Core will facilitate the following measurements:
(1) Quantification of AAAs
(2) Characterization of AAA composition
(3) Atherosclerosis lesion quantification and composition
(4) Plasma Measurements

Representative Publications

1. King VL, Trivedi D, Gitlin J.R., Loftin CD. (2006 )Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol May;26(5):1137-43
2. Henriques TA, Huang J, D'Souza SS, Daugherty A, Cassis LA. (2004) Orchidectomy, but not ovariectomy angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology. 2004;145:3866-3872.
3. Cassis LA, Helton MJ, Howatt DA, King VL, Daugherty A. (2005) Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Brit J Pharm.144:443-8.
4. Daugherty A, Cassis LA. (2004) Angiotensin II mediated development of vascular diseases. Trends Cardiovasc. Med. 14:117-120.
5. Daugherty A, Cassis LA. (2004) Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 24:429-434.
6. Saraff KF, Babamusta F, Cassis LA, Daugherty A. (2003) Aortic dissection precedes formation of aneurysms and atherosclerosis in AngII-infused apoE deficient mice. Arterioscler Thromb Vasc Biol. 23: 1621-1620
7. Manning MW, Cassis LA, Daugherty A. (2003) Differential effects of doxycycline, a broad spectrum inhibitor of matrix metalloproteinases, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 23: 468-476.
8. Manning MW, Cassis LA, Huang J, Szilvassy SJ, and Daugherty A (2002) Aortic aneurysms: Fresh insights from a novel animal model. Vasc Med. 7: 45-54
9. Daugherty A, Cassis LA (2002) Mechanisms of arterial aneurysm formation. Current Athero Reports. 4:222-227.
10. Daugherty A, Manning MW, Cassis LA. (2001) Contrasting effects of AT1 and AT2 antagonism on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Brit J Pharmacol. 134: 865-870
11. Daugherty A, Cassis LA. (2002) Angiotensin promotes atherosclerotic lesions and aneurysms in apolipoprotein E deficient -/- mice. J Clin Invest. 105:1605-1612.
12. Cassis L, and Daugherty A. (1999) Chronic angiotensin II infusion promotes atherogenesis in LDL receptor -/- mice. Ann NY Acad Sci 892:108-118.