Interdisciplinary Cardiovascular Training Grant Publications (T32HL072743)

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New developments in selective cholesteryl ester uptake. Meyer JM, Graf GA, van der Westhuyzen DR. Curr Opin Lipidol. 2013 Oct;24(5):386-92. doi: 10.1097/MOL.0b013e3283638042. Review. PMID: 23842142

Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F. Guo HF, Li X, Parker MW, Waltenberger J, Becker PM, Vander Kooi CW. Biochemistry. 2013 Oct 29;52(43):7551-8. doi: 10.1021/bi401034q. Epub 2013 Oct 18. PMID: 24079887. PMCID:PMC3873856

The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. Scotland RL, Allen L, Hennings LJ, Post GR, Post SR. PLoS One. 2013 Sep 17;8(9):e73599. doi: 10.1371/journal.pone.0073599. PMID: 24069211. PMCID:PMC3775766

Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice. Helsley RN, Sui Y, Ai N, Park SH, Welsh WJ, Zhou C. Mol Pharmacol. 2013 Jun;83(6):1190-9. doi: 10.1124/mol.113.085753. Epub 2013 Mar 21. PMID:23519392. PMCID:PMC3657097

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition.  Parker M.W., Xu P., Guo, H-F., Vander Kooi C.W. (2012) PLoS ONE 2012;7(11):e49177. doi: 10.1371/journal.pone.0049177. PMID:23145112. PMCID:PMC3493496

Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors. Parker M.W., Guo, H-F., Li, X., Linkugel, A.D., Vander Kooi C.W. (2012)  Biochemistry, 51(47), 9437-9446. PMID:23116416. PMCID:PMC3510667

Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia. Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):52-9. doi: 10.1161/ATVBAHA.112.300527. Epub 2012 Oct 25. PMID:23104851. PMCID:PMC3524385

Myeloid-specific IκB kinase β deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice. Park SH, Sui Y, Gizard F, Xu J, Rios-Pilier J, Helsley RN, Han SS, Zhou C. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2869-76. doi: 10.1161/ATVBAHA.112.254573. Epub 2012 Sep 27. PMID:23023371

Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice. Putnam K, Batifoulier-Yiannikouris F, Bharadwaj KG, Lewis E, Karounos M, Daugherty A, Cassis LA. Endocrinology. 2012 Oct;153(10):4677-86. Epub 2012 Aug 23. PMID:22919058. PMCID:PMC3512029

Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. Yang F, Dong A, Mueller P, Caicedo J, Sutton AM, Odetunde J, Barrick CJ, Klyachkin YM, Abdel-Latif A, Smyth SS. PLoS One. 2012;7(8):e40196. doi: 10.1371/journal.pone.0040196. Epub 2012 Aug 20. PMID:22916095. PMCID:PMC3423413

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1. Parker M.W., Xu P., Li X., Vander Kooi C.W. (2012)  J. Biol. Chem. 287(14):11082-9. PMID:22318724. PMCID:PMC3322888

Lipid phosphate phosphatase (LPP3) and vascular development. Ren H, Panchatcharam M, Mueller P, Escalante-Alcalde D, Morris AJ, Smyth SS. Biochim Biophys Acta. 2013 Jan;1831(1):126-32. doi: 10.1016/j.bbalip.2012.07.012. Epub 2012 Jul 24. Review. PMID:22835522. PMCID:PMC3683602

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation. Meyer JM, Ji A, Cai L, van der Westhuyzen DR. J Lipid Res. 2012 Oct;53(10):2081-91. doi: 10.1194/jlr.M026534. Epub 2012 Jul 25. PMID:22833685. PMCID:PMC3435541

Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Boyanovsky BB, Bailey W, Dixon L, Shridas P, Webb NR. Am J Pathol. 2012 Sep;181(3):1088-98. doi: 10.1016/j.ajpath.2012.05.037. Epub 2012 Jul 17. PMID:22813854. PMCID:PMC3432434

iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. Calderon LE, Liu S, Su W, Xie Z, Guo Z, Eberhard W, Gong MC. PLoS One. 2012;7(2):e31850. doi: 10.1371/journal.pone.0031850. Epub 2012 Feb 20. PMID:22363752. PMCID:PMC3282780

Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia-reperfusion-induced kidney injury. Li Y, Tong X, Maimaitiyiming H, Clemons K, Cao JM, Wang S. Am J Physiol Renal Physiol. 2012 Mar 1;302(5):F561-70. doi: 10.1152/ajprenal.00355.2011. Epub 2011 Dec 7. PMID:22160771. PMCID:PMC3353645

Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model. Li Y, Tong X, Rumala C, Clemons K, Wang S. PLoS One. 2011;6(10):e26656. doi: 10.1371/journal.pone.0026656. Epub 2011 Oct 24. PMID:22039525. PMCID:PMC3200349

Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):24-32. doi: 10.1161/ATVBAHA.111.234708. Epub 2011 Oct 20. PMID:22015657. PMCID:PMC3241874

SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation. Nikolic D, Calderon L, Du L, Post SR. BMC Immunol. 2011 Jul 7;12:37. doi: 10.1186/1471-2172-12-37. PMID:21736734. PMCID:PMC3141791

Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER. Smith JL, McBride CM, Nataraj PS, Bartos DC, January CT, Delisle BP. Am J Physiol Cell Physiol. 2011 Jul;301(1):C75-85. doi: 10.1152/ajpcell.00494.2010. Epub 2011 Apr 13. PMID:21490315. PMCID:PMC3129823

p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury. Velez JM, Miriyala S, Nithipongvanitch R, Noel T, Plabplueng CD, Oberley T, Jungsuwadee P, Van Remmen H, Vore M, St Clair DK. PLoS One. 2011 Mar 30;6(3):e18005. doi: 10.1371/journal.pone.0018005. PMID:21479164. PMCID:PMC3068154

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation. Bartos DC, Duchatelet S, Burgess DE, Klug D, Denjoy I, Peat R, Lupoglazoff JM, Fressart V, Berthet M, Ackerman MJ, January CT, Guicheney P, Delisle BP. Heart Rhythm. 2011 Jan;8(1):48-55. doi: 10.1016/j.hrthm.2010.09.010. Epub 2010 Sep 17. PMID:20850564

Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation. Pang C, Crump SM, Jin L, Correll RN, Finlin BS, Satin J, Andres DA. Channels (Austin). 2010 May-Jun;4(3):192-202. Epub 2010 May 1. PMID:20458179. PMCID:PMC3059075

Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic function. Li WY, Strang SE, Brown DR, Smith R, Silcox DL, Li SG, Baldridge BR, Nesselroade KP Jr, Randall DC. Auton Neurosci. 2010 Apr 19;154(1-2):48-53. doi: 10.1016/j.autneu.2009.11.003. Epub 2009 Dec 16. PMID: 20018569. PMCID:PMC2844913

Regulation of blood and vascular cell function by bioactive lysophospholipids. Morris AJ, Panchatcharam M, Cheng HY, Federico L, Fulkerson Z, Selim S, Miriyala S, Escalante-Alcalde D, Smyth SS. J Thromb Haemost. 2009 Jul;7 Suppl 1:38-43. doi: 10.1111/j.1538-7836.2009.03405.x. Review. PMID: 19630765. PMCID:PMC2801156

Parasympathetic response to acute stress is attenuated in young Zucker obese rats. El-Wazir YM, Li SG, Smith R, Silcox DL, Brown DR, Randall DC. Auton Neurosci. 2008 Dec 5;143(1-2):33-9. doi: 10.1016/j.autneu.2008.07.004. Epub 2008 Aug 22. PMID: 18722824. PMCID:PMC2620042

Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids. Correll RN, Botzet GJ, Satin J, Andres DA, Finlin BS. Cell Signal. 2008 Feb;20(2):400-8. Epub 2007 Nov 6. PMID: 18068949. PMCID:PMC2276613

Calmodulin binding is dispensable for Rem-mediated Ca2+ channel inhibition. Correll RN, Pang C, Niedowicz DM, Satin J, Andres DA. Mol Cell Biochem. 2008 Mar;310(1-2):103-10. Epub 2007 Dec 4. PMID: 18057997

The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling. Correll RN, Pang C, Niedowicz DM, Finlin BS, Andres DA. Cell Signal. 2008 Feb;20(2):292-300. Epub 2007 Nov 6. Review. PMID: 18042346. PMCID:PMC2254326

Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition. Correll RN, Pang C, Finlin BS, Dailey AM, Satin J, Andres DA. J Biol Chem. 2007 Sep 28;282(39):28431-40. Epub 2007 Aug 7. PMID: 17686775. PMCID:PMC3063359

Molecular factor computing for predictive spectroscopy. Dai B, Urbas A, Douglas CC, Lodder RA. Pharm Res. 2007 Aug;24(8):1441-9. Epub 2007 Mar 23. PMID: 17380265

Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice. Bostrom MA, Boyanovsky BB, Jordan CT, Wadsworth MP, Taatjes DJ, de Beer FC, Webb NR. Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):600-6. Epub 2007 Jan 4. PMID: 17204667

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