Training Program Activity for Clinical Scholars in
 Cardiovascular Science T32HL091812

ERK1/2 activation is a therapeutic target in age-related macular degeneration. Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J.. Proc Natl Acad Sci U S A. 2012 Aug 6. PMID: 22869729, PMCID:PMC3427082

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. Nature. 2011 Mar 17;471(7338):325-30. Epub 2011 Feb 6. PMID: 21297615 

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Mol Ther. 2012 Jan;20(1):101-8. doi: 10.1038/mt.2011.212. Epub 2011 Oct 11. PMID: 21988875 

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. Cell. 2012 May 11;149(4):847-592012 Apr 26. PMID: 22541070 

Eastwood JA, Doering LV, Dracup K, Evangelista L, Hays RD. Health-related quality of life: The impact of diagnostic angiography. Heart Lung. 2010 Aug 5e Pub. PMIC – in progress

Rutledge T, Linke SE, Johnson BD, Bittner V, Krantz DS, Whittaker KS, Eastwood JA, Eteiba W, Cornell CE, Pepine CJ, Vido DA, Olson MB, Shaw LJ, Vaccarino V, Bairey Merz CN. Self-rated versus objective health indicators as predictors of major cardiovascular events: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. Psychosom Med. 2010 Jul;72(6):549-55. PMIC – in progress

Doering LV, Eastwood JA. A literature review of depression, anxiety, and cardiovascular disease in women. J Obstet Gynecol Neonatal Nurs. 2011 Apr 8. PMIC – in progress

Eastwood JA, Doering LV, Dracup K, Evangelista L, Hays RD. Health-related quality of life: The impact of diagnostic angiography. Heart Lung. 2010 Aug 5e Pub. PMIC – in progress

Haggerty CM, Kramer SP, Binkley CM, Powell DK, Mattingly AC, Charnigo R, Epstein FH, Fornwalt BK.  Reproducibility of cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance for measuring left ventricular strains, torsion, and synchrony in mice.  J Cardiovasc Magn Reson. 2013 Aug 27;15(1):71. PMID: 23981339

Kinner J. and Zwishchenberger J. Lung reductions surgery open technique. In Atlas of Thoracic Surgical Techniques (J. Zwischenberger, ed.)

Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Mol Ther. 2012 Jan;20(1):101-8. doi: 10.1038/mt.2011.212. Epub 2011 Oct 11. PMID: 21988875 

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. Nature. 2011 Mar 17;471(7338):325-30. Epub 2011 Feb 6. PMID: 21297615 

Kleinman ME, Greives MR, Churgin, SS, Blechman KM, Ceradini, DJ, Chang, E, Blei, F, Gurtner, GC. 2006. Hypoxic Mediators of Progenitor Cell Mobilization and Recruitment Are Increased in Children with Hemangioma. Arteriosclerosis, Thrombosis, and Vascular Biology. 27(12); 2664-70.

Kleinman ME, Baffi JZ, Ambati J. The Multifactorial Nature of Retinal Vascular Disease. Ophthalmologica Res. 2010 Aug 18.  PubMed PMID:  20714177.

Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, Albuquerque RJC, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Shibuya M, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor EW, Ambati J. 2008. Sequence- and target-independent suppression of angiogenesis by siRNA. Nature. 452(7187): 591-7.

Kleinman ME and Ambati J. 2008. Fifty years later: the disk goes to the prom. Journal of Clinical Investigation. 118(8): 2681-4.

Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J and Zhang K. 2008. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. New England Journal of Medicine. 359(14): 1456-63.

Cho WG, Albuquerque RJC, Kleinman ME, Tarallo, V, Greco A, Nozaki M, Rich MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J. 2009. Small interfering RNA induced TLR3 activation inhibits blood and lymphatic vessel growth. Proceedings of the National Academy of Sciences. 106, 7137-42.

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJC, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J. 2009. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 460(7252):225-30.

Albuquerque RJC, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H,  Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. 2009. Alternatively spliced VEGF receptor-2 is an essential endogenous inhibitor of lymphatic vessels. Nature Medicine. 15(9):1023-30.

Kleinman ME, Baffi JZ, Ambati, J. 2010. The Multifactorial Nature of Retinal Vascular Disease. Ophthalmologica 224 S1: 16-24. (PMIC – in progress)

Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3. Mol Ther. 2011 Oct 11. doi: 10.1038/mt.2011.212. [Epub ahead of print] (PMIC – in progress)

Pharmacy Residency Critical Care Conference, University of Kentucky

Oestreich JH, Holt J, Dunn SP, Smyth SS, Campbell CL, Charnigo R, Akers WS, Steinhubl SR. Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel. Coron Artery Dis. 2009 Mar. 
PMID: 19318928

Oestreich JH and Steinhubl SR. Cangrelor in percutaneous coronary intervention. Expert Rev Clin Pharmacol 2009 Mar;2(2):137-145.

Steinhubl SR, Oh JJ, Oestreich JH, Ferraris S, Charnigo R, Akers WS. Transitioning patients from cangrelor to clopidogrel: Pharmacodynamic evidence of a competitive effect. Thromb Res 2008;121:527-534. 
PMID: 17631948

Oestreich JH. Elinogrel, a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. Curr Opin Investig Drugs.2010 Mar;1:340-348. PMID:20178048.

Akers WS, Oh JJ, Oestreich JH, Ferraris S, Wethington M, Steinhubl SR.  Pharmacokinetics and pharmacodynamics of a bolus and infusion of cangrelor: a direct, parenteral P2Y12 receptor antagonist.   J Clin Pharmacol. 2010;50(1):27-35. PMID:19779037.

Oestreich JH and Steinhubl SR.  Cangrelor: Pharmacology in the Catheterization Laboratory.  Ed. Ron Waksman and Andrew Ajani. Chichester: Blackwell Publishing, 2010. 53-58.

Oestreich J. SCH-530348, a thrombin receptor (PAR-1) antagonist, for the prevention and treatment of atherothrombosis.  Curr Opin Investig Drugs.2009 Sep;10(9):988-996. PMID:19705342.

Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS. Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Adv Hematol. 2012;2012:924042. Epub 2012 Aug 7. PMID: 22919395; PMCID: PMC3420227.

Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Selim S, Sunkara M, Salous AK, Leung SW, Berdyshev EV, Bailey A, Campbell CL, Charnigo R, Morris AJ, Smyth SS. Clin Sci (Lond). 2011 Dec;121(12):565-72. PMID: 21749329 

Plasma levels of the bioactive lipid mediator sphingosphine-1-phosphate correlate with hematocrit, but are variably affected by red blood cell transfusion.  Selim S, Leung S, Dasgupta A, Haughton M, Caicedo J, Bailey A, Campbell C, Smyth SS, and Morris AJ.  (2009) ATVB, 29(7) e.

Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice. Yiannikouris F, Gupte M, Putnam K, Thatcher S, Charnigo R, Rateri DL, Daugherty A, Cassis LA. Hypertension. 2012 Oct 29. PMID: 23108647.

Deficiency of Angiotensin Type 1a Receptors in Adipocytes Reduces Differentiation and Promotes Hypertrophy of Adipocytes in Lean Mice. Putnam K, Batifoulier-Yiannikouris F, Bharadwaj KG, Lewis E, Karounos M, Daugherty A, Cassis LA. Endocrinology. 2012 Aug 23. PMID: 22919058  

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Yiannikouris F, Karounos M, Charnigo R, English VL, Rateri DL, Daugherty A, Cassis LA. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R244-51. Epub 2011 Nov 9. PMID: 22071160 

Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. Gupte M, Thatcher SE, Boustany-Kari CM, Shoemaker R, Yiannikouris F, Zhang X, Karounos M, Cassis LA. Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1392-9. Epub 2012 Mar 29. PMID: 22460555 

The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. Putnam K, Shoemaker R, Yiannikouris F, Cassis LA. Am J Physiol Heart Circ Physiol. 2012 Mar;302(6):H1219-30. Epub 2012 Jan 6. Review. PMID: 22227126 

Yiannikouris F, Gupte M, Putnam K, Cassis L.  Adipokines and blood pressure control. Curr Opin Nephrol Hypertens. 2010 Mar;19(2):195-200. PMID: 20051852 

Yiannikouris F, Karounos K, Richard Charnigo, English V, Rateri D, Daugherty A and Cassis L. Adipocytes deficiency of Angiotensinogen decreases the systolic blood pressure in older male mice. American Journal of Physiology – Regulatory and Comparative and integrative physiology, 2011

Gupte M, Thatcher SE, Boustany-Kari CM, Shoemaker R, Yiannikouris F, Zhang X, Karounos M, Cassis LA.  Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57bl/6 Mice. Arterioscler Thromb Vasc Biol. 2012 Mar 29. PMID: 22460555