Saha CVRC Publications Archive

Archived Publications

Lipid Phosphate Phosphatase 3 Negatively Regulates Smooth Muscle Cell Phenotypic Modulation to Limit Intimal Hyperplasia. Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS. Arterioscler Thromb Vasc Biol. 2012 Oct 25. PMID: 23104851

The Src family kinases and PKC synergize to mediate Gq-dependent platelet activation. Xiang B, Zhang G, Stefanini L, Bergmeier W, Gartner TK, Whiteheart SW, Li Z. J Biol Chem. 2012 Nov 30;287(49):41277-87. doi: 10.1074/jbc.M112.393124. PMID: 23066026

Doxycycline Does Not Influence Established Abdominal Aortic Aneurysms in Angiotensin II-Infused Mice. Xie X, Lu H, Moorleghen JJ, Howatt DA, Rateri DL, Cassis LA, Daugherty A. PLoS One. 2012;7(9):e46411. doi: 10.1371/journal.pone.0046411. Epub 2012 Sep 27. PMID: 23029514

Durability of glycemic control using U-500 insulin. Dailey AM, Gibert JA, Tannock LR. Diabetes Res Clin Pract. 2012 Mar;95(3):340-4. Epub 2011 Nov 15. PMID: 22088791

Endogenous Androgen Deficiency Enhances Diet-Induced Hypercholesterolemia and Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Hatch NW, Srodulski SJ, Chan HW, Zhang X, Tannock LR, King VL. Gend Med. 2012 Sep 12. pii: S1550-8579(12)00160-X. doi: 10.1016/j.genm.2012.08.003. PMID: 22981166

Do vivarium conditions influence atherosclerotic lesion size? Daugherty A, Rateri DL. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2339-40. PMID: 22972938

Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Clin Sci (Lond). 2012 Nov;123(9):531-43. Review. PMID: 22788237

Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. Cai L, Wang Z, Ji A, Meyer JM, van der Westhuyzen DR. PLoS One. 2012;7(5):e36785. Epub 2012 May 16. PMID: 22615812

Deficiency of Angiotensin Type 1a Receptors in Adipocytes Reduces Differentiation and Promotes Hypertrophy of Adipocytes in Lean Mice. Putnam K, Batifoulier-Yiannikouris F, Bharadwaj KG, Lewis E, Karounos M, Daugherty A, Cassis LA. Endocrinology. 2012 Oct;153(10):4677-86. Epub 2012 Aug 23. PMID: 22919058

Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. Yang F, Dong A, Mueller P, Caicedo J, Sutton AM, Odetunde J, Barrick CJ, Klyachkin YM, Abdel-Latif A, Smyth SS. PLoS One. 2012;7(8):e40196. Epub 2012 Aug 20. PMID: 22916095; PMCID: PMC3423413.

Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS. Adv Hematol. 2012;2012:924042. Epub 2012 Aug 7. PMID: 22919395; PMCID: PMC3420227.

Citrullus lanatus 'sentinel' (watermelon) extract reduces atherosclerosis in LDL receptor-deficient mice. Poduri A, Rateri DL, Saha SK, Saha S, Daugherty A. J Nutr Biochem. 2012 Aug 16. PMID: 22902326

Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient mice. Tang T, Thompson JC, Wilson PG, Nelson C, Williams KJ, Tannock LR. Connect Tissue Res. 2012 Jul 26. PMID: 22834985

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation. Meyer JM, Ji A, Cai L, van der Westhuyzen DR. J Lipid Res. 2012 Jul 25. PMID: 22833685

Novel Mechanisms of Abdominal Aortic Aneurysms. Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Curr Atheroscler Rep. Epub 2012 Jul 26. 2012 Oct;14(5):402-12. doi: 10.1007/s11883-012-0271-y. Review PMID: 22833280

Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA. Circ Res. 2012 May 25;110(11):e73-85. Epub 2012 Apr 26. PMID: 22539767

C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. Nucleic Acids Res. 2012 May;40(9):4025-39. PMID: 22210893

Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A. Clin Sci (Lond). 2012 Nov 1;123(9):531-43. PMID: 22788237

iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. Calderon LE, Liu S, Su W, Xie Z, Guo Z, Eberhard W, Gong MC. PLoS One. 2012;7(2):e31850. Epub 2012 Feb 20. PMID: 22363752

Invasive coronary vasoreactivity testing to diagnose microvascular dysfunction in women. Bailey AL, Smyth SS. JACC Cardiovasc Interv. 2012 Jun;5(6):654-5. PMID: 22721661

The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independent of phytosterol accumulation. Su K, Sabeva NS, Liu J, Wang Y, Bhatnagar S, van der Westhuyzen DR, Graf GA. J Biol Chem. 2012 Aug 17;287(34):28564-75. doi: 10.1074/jbc.M112.360081. PMID: 22715101. PMCID:PMC3436556

Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. Cantrell Stanford J, Morris AJ, Sunkara M, Popa GJ, Larson KL, Özcan S. J Biol Chem. 2012 Apr 13;287(16):13457-64. Epub 2012 Mar 2. PMID: 22389505

Preventing Platelet Thrombosis with a PAR1 Pepducin. Abdel-Latif A, Smyth SS. Circulation. 2012 Jun 15. PMID: 22705888

Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice. Lu H, Wu C, Howatt DA, Balakrishnan A, Charnigo RJ Jr, Cassis LA, Daugherty A. J Nutr Biochem. 2012 Jun 15. PMID: 22705323

The New ATVB Editorial Team. Daugherty A. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1545. PMID: 22699272

Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study. Wallace EL, Smyth SS. J Thromb Thrombolysis. EPub 2012 Jun 10. 2012 Nov;34(4):548-51. doi: 10.1007/s11239-012-0754-2. PubMed PMID: PMID: 22684577

Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice. Subramanian V, Uchida HA, Ijaz T, Moorleghen JJ, Howatt DA, Balakrishnan A. J Cardiovasc Pharmacol. 2012 Jan;59(1):66-76. PMID: 21964156

Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke. Han SG, Howatt DA, Daugherty A, Gairola CG. Toxicology. 2012 Sep 28; 299(2-3):133-8. doi: 10.1016/j.tox.2012.05.015. PMID: 22659316

Meta-analysis of long-term outcomes for drug-eluting stents versus bare-metal stents in primary percutaneous coronary interventions for ST-segment elevation myocardial infarction. Wallace EL, Abdel-Latif A, Charnigo R, Moliterno DJ, Brodie B, Matnani R, Ziada KM. Am J Cardiol. 2012 Apr 1;109(7):932-40. Epub 2012 Jan 3. Review. PMID: 22221949

Scavenger Receptor CD36 Expression Contributes to Adipose Tissue Inflammation and Cell Death in Diet-Induced Obesity. Cai L, Wang Z, Ji A, Meyer JM, van der Westhuyzen DR. PLoS One. 2012;7(5):e36785. Epub 2012 May 16. PMID: 22615812

Smooth Muscle-Specific Expression of iPLA2β Participates in the Initiation and Early Progression of Vascular Inflammation and Neointima Formation. Liu S, Xie Z, Zhao Q, Pang H, Turk J, Calderon L, Su W, Zhao G, Xu H, Gong MC, Guo Z. J Biol Chem. 2012 Jul 13;287(29):24739-53. Epub 2012 May 25. PMID: 22637477

Macrophage SR-BI regulates pro-inflammatory signaling in mice and isolated macrophages. Cai L, Wang Z, Ji A, Meyer JM, van der Westhuyzen DR. J Lipid Res. 2012 May 15. PMID: 22589557

Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity. Findeisen HM, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, Bruemmer D. Obesity (Silver Spring). 2011 Dec;19(12):2429-32. doi: 10.1038/oby.2011.298. Epub 2011 Sep 29. PMID: 21959341

Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM. Cancer Res. 2012 Mar 15;72(6):1504-17. Epub 2012 Jan 19. PMID: 22266115

The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid. Liu J, Liang S, Liu X, Brown JA, Newman KE, Sunkara M, Morris AJ, Bhatnagar S, Li X, Pujol A, Graf GA. J Lipid Res. 2012 Jun;53(6):1071-9. Epub 2012 Apr. PMID: 22493092

Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysms. Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA. Circ Res. 2012 Apr 26. PMID: 22539767

Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice. Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS. Mol Endocrinol. 2012 May;26(5):786-97. Epub 2012 Apr 3. PMID: 22474126

Altered clock gene expression and vascular smooth muscle diurnal contractile variations in type 2 diabetic db/db mice. Su W, Xie Z, Guo Z, Duncan MJ, Lutshumba J, Gong MC. Am J Physiol Heart Circ Physiol. 2012 Feb;302(3):H621-33. Epub 2011 Dec 2. PMID: 22140039

Elevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance. Mohammed N, Tang L, Jahangiri A, de Villiers W, Eckhardt E. Metabolism. 2012 Mar 17. PMID: 22424821

Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells. Subramanian V, Golledge J, Heywood EB, Bruemmer D, Daugherty A. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):397-405. Epub 2011 Nov 17. PMID: 22095985

Creating biodegradable-polymer drug-eluting stents: shortening the duration of polymer and dual antiplatelet therapy while lengthening the follow-up. Abdel-Latif A, Moliterno DJ. Catheter Cardiovasc Interv. 2012 Feb 1;79(2):217-8. doi: 10.1002/ccd.24294. PMID: 22271552

iPLA(2)β Overexpression in Smooth Muscle Exacerbates Angiotensin II-Induced Hypertension and Vascular Remodeling. Calderon LE, Liu S, Su W, Xie Z, Guo Z, Eberhard W, Gong MC. PLoS One. 2012;7(2):e31850. Epub 2012 Feb 20. PMID: 22363752; PMCID: PMC3282780.

Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles. Xie Z, Liu D, Liu S, Calderon L, Zhao G, Turk J, Guo Z . J Biol Chem. 2011 Dec 30;286(52):44646-58. Epub 2011 Nov 4. PMID: 22057271; PMCID: PMC3247950.

PIPKIγ regulates focal adhesion dynamics and colon cancer cell invasion. Wu Z, Li X, Sunkara M, Spearman H, Morris AJ, Huang C. PLoS One. 2011;6(9):e24775. Epub 2011 Sep 12. PMID: 21931851; PMCID: PMC3171478.

Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):24-32. Epub 2011 Oct 20. PMID: 22015657; PMCID: PMC3241874.

MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4. Owens AP 3rd, Rateri DL, Howatt DA, Moore KJ, Tobias PS, Curtiss LK, Lu H, Cassis LA, Daugherty A. 2011 Sep 29. PMID: 21960563; PMCID: PMC3220737. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2813-9.

Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Uchida HA, Poduri A, Subramanian V, Cassis LA, Daugherty A. Epub 2011 Aug 25. PubMed PMID: 21868698; PMCID: PMC3220732.  Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2845-52.

Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review Wu C, Lu H, Cassis L, Daugherty A.  N A J Med Sci. 2011;4(4):183-190. PubMed PMID: 22389749.

Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null mice. Habegger KM, Grant E, Pfluger PT, Perez-Tilve D, Daugherty A, Bruemmer D, Tschöp MH and Hofmann SM.  Front. Endocrin. 2:67. doi: 10.3389/fendo.2011.00067.

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. J Clin Invest. 2012 Jan 3. pii: 58969. doi: 10.1172/JCI58969. PMID: 22214850.

Targeting angiogenesis as treatment for obesity. Bruemmer D. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):161-2. PMID: 22258895.

Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer. FZaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor KL, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM. Cancer Res. 2012 Jan 19. PMID: 22266115.

Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice Feng H, Guo L, Wang D, Gao H, Hou G, Zheng Z, Ai J, Foreman O, Daugherty A, Li XA. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2543-51. PMID: 21836069; PMCID: PMC3202973.

Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms. Bruemmer D, Daugherty A, Lu H, Rateri DL. Ann N Y Acad Sci. 2011 Dec;1245(1):7-10. doi: 10.1111/j.1749-6632.2011.06332.x. PMID: 22211965.

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. GZhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z. J Biol Chem. 2011 Nov 11;286(45):39466-77. Epub 2011 Sep 22. PMID: 21940635; PMCID: PMC3234770.

Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms. Wang S, Subramanian V, Lu H, Howatt DA, Moorleghen JJ, Charnigo R, Cassis LA, Daugherty A. Atherosclerosis. 2011 Nov 19. PubMed PMID: 22153700.

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1 and SR-BI. Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR. J Lipid Res. 2011 Dec 20. [Epub ahead of print] PubMed PMID: 22190590.

Platelet-Mediated Thrombosis and Drug-Eluting Stents. Granada JF, Price MJ, French PA, Steinhubl SR, Cutlip DE, Becker RC, Smyth SS, Dauerman HL. Circ Cardiovasc Interv. 2011 Dec 1;4(6):629-637. PubMed PMID: 22186107.

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Blood. 2011 Sep 29;118(13):3670-9. Epub 2011 Jul 29. PMID: 21803853.

Regulation of Peroxisome Proliferator-Activated Receptor-γ by Angiotensin II Via Transforming Growth Factor-β1-Activated p38 Mitogen-Activated Protein Kinase in Aortic Smooth Muscle Cells. Subramanian V, Golledge J, Heywood EB, Bruemmer D, Daugherty A. Arterioscler Thromb Vasc Biol. 2011 Nov 17. PubMed PMID: 22095985.

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms. Daugherty A, Cassis LA, Lu H. J Zhejiang Univ Sci B. 2011 Aug;12(8):624-8. Review. PubMed PMID: 21796801; PubMed Central PMCID: PMC3150714.

Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm. Rateri DL, Howatt DA, Moorleghen JJ, Charnigo R, Cassis LA, Daugherty A. Am J Pathol. 2011 Sep;179(3):1542-8. Epub 2011 Jul 19. PubMed PMID: 21763672; PubMed Central PMCID: PMC3157213.

Durability of glycemic control using U-500 insulin. Dailey AM, Gibert JA, Tannock LR. Diabetes Res Clin Pract. 2011 Nov 14. PubMed PMID: 22088791.

Identification of a cAMP-response element in the RGS2 promoter as a Key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured VSMC. Xie Z, Liu D, Liu S, Calderon L, Zhao G, Turk J, Guo Z. J Biol Chem. 2011 Nov 4. [Epub ahead of print] PubMed PMID: 22057271.

Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Arterioscler Thromb Vasc Biol. 2011 Oct 20. PMID: 22015657.

Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis. Lu H, Balakrishnan A, Howatt DA, Wu C, Charnigo R, Liau G, Cassis LA, Daugherty A. Br J Pharmacol. 2011 2012 Mar;165(6):2000-8. doi: 10.1111/j.1476-5381.2011.01712.x. PMID: 22014125.

Ursolic acid effect on atherosclerosis: Apples and apples, or apples and oranges? Tannock LR. Atherosclerosis. 2011 Sep 28. PMID: 21993411.

MyD88 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4. Owens AP 3rd, Rateri DL, Howatt DA, Moore KJ, Tobias PS, Curtiss LK, Lu H, Cassis LA, Daugherty A. Arterioscler Thromb Vasc Biol. 2011 Sep 29. PMID: 21960563.

Calpain Inhibition Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms and Atherosclerosis in LDL Receptor Deficient Mice. Subramanian V, Uchida HA, Ijaz T, Moorleghen JJ, Howatt DA, Balakrishnan A. J Cardiovasc Pharmacol. 2011 Sep 29. PMID: 21964156.

Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells. Gizard F, Zhao Y, Findeisen HM, Qing H, Cohn D, Heywood EB, Jones KL, Nomiyama T, Bruemmer D. J Biol Chem. 2011 Oct 14;286(41):35485-93. Epub 2011 Aug 25. PubMed PMID: 21868379; PubMed Central PMCID: PMC3195596.

Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-Like Receptors 2 and 4. Owens AP 3rd, Rateri DL, Howatt DA, Moore KJ, Tobias PS, Curtiss LK, Lu H, Cassis LA, Daugherty A. MyD88 Deficiency Attenuates Angiotensin II-Induced Arterioscler Thromb Vasc Biol. 2011 Sep 29. PMID: 21960563.

Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase. Wroblewski JM, Jahangiri A, Ji A, de Beer FC, van der Westhuyzen DR, Webb NR. J Lipid Res. 2011 Dec;52(12):2255-61. Epub 2011 Sep 27. PMID: 21957202.

Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity. Zhang X, Hurng J, Rateri DL, Daugherty A, Schmid-Schönbein GW, Shin HY. Am J PhysiolCell Physiol. 2011 Aug;301(2):C451-60. Epub 2011 Apr 27. PubMed PMID: 21525434; Central PMCID: PMC3154559.

Distinct roles for Rap1b in platelet secretion and integrin [alpha]IIb[beta]3 outside-in signaling. Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z. J Biol Chem. 2011 Sep 22. PMID: 21940635.

PIPKIγ Regulates Focal Adhesion Dynamics and Colon Cancer Cell Invasion. Wu Z, Li X, Sunkara M, Spearman H, Morris AJ, Huang C. PLoS One. 2011;6(9):e24775. Epub 2011 Sep 12. PMID: 21931851; Central PMCID: PMC3171478.

C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake. Guo L, Chen M, Song Z, Daugherty A, Li XA. J Lipid Res. 2011 Dec;52(12):2272-8. Epub 2011 Sep 14. PMID: 21917726.

Race-ethnicity as an effect modifier of the association between HbAlc and mortality in U.S. adults without diagnosed diabetes. Kehl KG, Findeisen HM, Fardo DW, Bruemmer D, Mannino DM, Sanderson WT.  Eur J Endocrinol. 2011 Aug;165(2):275-81. Epub 2011 May 26. PMID: 21622476.

Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. Findeisen HM, Pearson KJ, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, de Cabo R, Bruemmer D. PLoS One. 2011 Apr 14;6(4):e18532. PMID: 21533223; Central PMCID: PMC3077372.

Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. Fulkerson Z, Wu T, Sunakura M, Vander Kooi C, Morris AJ, Smyth SS. J Biol Chem. 2011 Aug 10. PMID: 21832043.

Biphasic roles for soluble guanylyl cyclase in platelet activation. Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Blood. 2011 Jul 29. PubMed PMID: 21803853.

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms. Daugherty A, Cassis LA, Lu H. J Zhejiang Univ Sci B. 2011 Aug.;12(8):624-628. PubMed PMID: 21796801.

Extreme insulin resistance: indications and approaches to the use of U-500 insulin in type 2 diabetes mellitus. Dailey AM, Tannock LR. Curr Diab Rep. 2011 Apr;11(2):77-82. Review. PubMed PMID: 21161448.

Prolonged Infusion of Angiotensin II in apoE(-/-) Mice Promotes Macrophage Recruitment with Continued Expansion of Abdominal Aortic Aneurysm. Rateri DL, Howatt DA, Moorleghen JJ, Charnigo R, Cassis LA, Daugherty A. Am J Pathol. 2011 Jul 14. PMID: 21763672.

Atherosclerosis: cell biology and lipoproteins. Lu H, Daugherty A. Curr Opin Lipidol. 2011 Aug;22(4):322-3. PMID: 21743310.

Serum amyloid A in atherosclerosis. King VL, Thompson J, Tannock LR.Curr Opin Lipidol. 2011 Jul 2. PMID: 21734573.

Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy. Thompson J, Wilson P, Brandewie K, Taneja D, Schaefer L, Mitchell B, Tannock LR. Renal Am J Pathol. 2011 Jun 29. PubMed PMID: 21723246.

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP 3rd, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A. Circ Res. 2011 Mar 4;108(5):574-81. PubMed PMID: 21252156; PubMed Central PMCID: PMC3076204.

The case against routine aspirin use for primary prevention in low-risk adults. Bailey AL, Smyth SS, Campbell CL. Am Fam Physician. 2011 Jun 15;83(12):1387-90. PubMed PMID: 21671539.

Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Wang JA, Chen WA, Wang Y, Zhang S, Bi H, Hong B, Luo Y, Daugherty A, Xie X. Atherosclerosis. 2011 Mar 10. PubMed PMID: 21481872.

Group X Secretory Phospholipase A2 Enhances TLR4 Signaling in Macrophages. Shridas P, Bailey WM, Talbott KR, Oslund RC, Gelb MH, Webb NR. J Immunol. 2011 May 27. PubMed PMID: 21622863.

Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. Thatcher SE, Zhang X, Howatt DA, Lu H, Gurley SB, Daugherty A, Cassis LA. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):758-65. Epub 2011 Jan 20. PubMed PMID: 21252069; PubMed Central PMCID: PMC3086633.

Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition. Findeisen HM, Gizard F, Zhao Y, Qing H, Heywood EB, Jones KL, Cohn D, Bruemmer D. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60. Epub 2011 Jan 13. PubMed PMID: 21233448; PubMed Central PMCID: PMC3074344.

Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. Atherosclerosis. 2011 Jan;214(1):58-64. Epub 2010 Aug 19. PubMed PMID: 20833395; PubMed Central PMCID: PMC3005558.

ATP binding cassette G1-dependent cholesterol efflux during inflammation. de Beer MC, Ji A, Jahangiri A, Vaughan AM, de Beer FC, van der Westhuyzen DR, Webb NR. J Lipid Res. 2011 Feb;52(2):345-53. Epub 2010 Dec 7. PubMed PMID: 21138980; PubMed Central PMCID: PMC3023555.

T-Lymphocyte Responses to Intestinally Absorbed Antigens can Contribute to Adipose Tissue Inflammation and Glucose Intolerance During High Fat Feeding. Wang Y, Li J, Tang L, Wang Y, Charnigo R, de Villiers W, Eckhardt E. PLos One. 2010 Nov 11;5 (11):e13951. PubMed PMID: 21085605; PubMed Central PMCID:PMC2978720.

Membrane Cholesterol Modulates the Fluid Shear Stress Response of Polymorphonuclear Leukocytes via it's Effects on Membrane Fluidity. Zhang X, Hurng J, Rateri DL, Daugherty A, Schmid-Schonbein GW, Shin HY. Am J Physiol Cell Physiol. 2011 Apr 27. [Epub ahead of print] PubMed PMID: 21525434.

Oxidative Stress Accumulates in Adipose Tissue During Aging and Inhibits Adipogenesis. Findeisen HM, Pearson KJ, Gizard F, ZhaoY, Qing H, Jones KL, Cohn D, Heywood EB, de Cabo R, Bruemmer D. PLoS One. 2011 Apr 14;6 (4):e18532. PubMed PMID: 21533223.

Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy. Campbell CL, Steinhubl SR, Hooper WC, Jozic J, Smyth SS, Bernstein D, De Staercke C, Syros G, Negus BH, Stuckey T, Stone GW, Mehran R, Dangas G. J Thromb Thrombolysis. 2011 Feb;31(2):139-45. PMID: 20872045.

Scavenger Receptor SR-BI in Macrophage Lipid Metabolism. Ji A, Meyer JM, Cai L, Akinmusire A, deBeer MC, Webb NR, van der Westhuyzen DR. Arterioscler Thromb Vasc Biol. 2011 Apr 8. PMID: 21481393

Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. Gizard F, Heywood EB, Findeisen HM, Zhao Y, Jones KL, Cudejko C, Post GR, Staels B, Bruemmer D. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):245-52. Epub 2010 Nov PMID: 21106948; PMCID: PMC3025413

Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):253-60. Epub 2010 Nov 18. PMID: 21088250; PMCID: PMC3025410.

A G(i)-independent mechanism mediating Akt phosphorylation in platelets. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z. J Thromb Haemost. 2010 Sep;8(9):2032-41. doi: 10.1111/j.1538-7836.2010.03969.x. PMID: 20586915; PMCID: PMC2965800

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B. Toxicol Appl Pharmacol. 2011 Feb 15;251(1):41-9. Epub 2010 Dec 1. PMID: 21130106; PMCID: PMC3026064.

A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis. Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ. Mol Biol Cell. 2010 Sep 15;21(18):3171-81. Epub 2010 Jul 21. PubMed PMID: 20660155; PubMed Central PMCID: PMC2938383.

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism. Dong A, Caicedo J, Han SG, Mueller P, Saha S, Smyth SS, Gairola CG. . Thromb Res. 2010 Oct;126(4):e312-7. Epub 2010 May 10. PubMed PMID: 20451958; PubMed Central PMCID: PMC2921009.

Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis. Eckhardt ER, Witta J, Zhong J, Arsenescu R, Arsenescu V, Wang Y, Ghoshal S, de Beer MC, de Beer FC, de Villiers WJ. BMC Gastroenterol. 2010 Nov 10;10:133. PubMed PMID: 21067563; PubMed Central PMCID: PMC2992040.

Endothelial Cell-Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor-/- Mice. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP 3rd, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A.2011 Jan 20.  PubMed PMID: 21252156.

Angiotensin-Converting Enzyme 2 Deficiency in Whole Body or Bone Marrow-Derived Cells Increases Atherosclerosis in Low-Density Lipoprotein Receptor-/- Mice. Thatcher SE, Zhang X, Howatt DA, Lu H, Gurley SB, Daugherty A, Cassis LA. 2011 Jan 20. PubMed PMID: 21252069.

Impact of Serum Amyloid A on High Density Lipoprotein Composition and Levels. de Beer MC, Webb NR, Wroblewski JM, Noffsinger VP, Rateri DL, Ji A, van der Westhuyzen DR, de Beer FC. J Lipid Res. 2010 Nov;51(11):3117-25. Epub 2010 Jul 27. PubMed PMID: 20667817.

Animal models of atherosclerosis: more than mice. Atherosclerosis. Tannock LR, King VL. 2010 Sep;212(1):32-3. 2010 Jun 30. PubMed PMID: 20638066.

Atherosclerosis:Cell Biology and Lipoproteins.  Lu H, Daugherty A. Curr Opin Lipidol. 2010 Dec 21. PubMed PMID: 21206345.

Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition.  Findeisen HM, Gizard F. Zhao Y, Qing H, Heywood EB, Jones KL, Cohn D, Bruemmer D. Arterioscler Thromb Vasc Biol. 2011 Jan 13. PubMed PMID: 21233448.

Evidence of Mobilization of Pluripotent Stem Cells into Peripheral Blood of Patients with Myocardial Ischemia. Abdel-Latif A, Zuba-Surma EK, Ziada KM, Kucia M, Cohen DA, Kaplan AM, Van Zant G, Selim S, Smyth SS, Ratajczak MZ. Exp Hematol. Aug 26. PubMed PMID: 20800644.

ATP binding cassette G1-dependent cholesterol efflux during inflammation. De Beer MC, Ji A, Jahangiri A, Vaughan AM, De Beer FC, Van der Westhuyzen DR, Webb NR. J Lipid Res. 2010 Dec 7. PubMed PMID: 21138980.

Group X Secretory Phospholipase A2 Negatively Regulates Adipogenesis in Murine Models. Li X, Shridas P, Forrest K, Bailey W, Webb NR. FASEB J. 2010 Nov;24(11):4313-24. PubMed PMID: 20585029; PubMed Central PMCID: PMC297424.

Signaling During Platelet Adhesion and Activation. Li Z, Delaney MK, O'Brien KA, Du X. Epub. 2010 Nov. PubMed PMID: 21071698.

Extreme Insulin Resistance: Indications and Approaches to the Use of U-500 Insulin in Type 2 Diabetes Mellitus. Dailey AM, Tannock LR. Epub 2010 Dec.   PubMed PMID: 21161448.

Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach M, Choi YJ, Hennig B, Toborek M. J Neurosci Res. 2010 Oct;88(13):2859-68. PMID: 20564349; PMCID: PMC2919635.

Intensive glycemic control and cardiovascular disease: an update. Brown A, Reynolds LR, Bruemmer D. Nat Rev Cardiol. 2010 Jul;7(7):369-75. Epub 2010 Apr 20. Review. PubMed PMID: 20404853.

Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Uchida HA, Kristo F, Rateri DL, Lu H, Charnigo R, Cassis LA, Daugherty A. Atherosclerosis. 2010 Aug;211(2):399-403. Epub 2010 Mar 4. PubMed PMID: 20362292; PubMed Central PMCID: PMC2900415.

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B. Toxicol Appl Pharmacol. 2010 Dec 1. PubMed PMID: 21130106.

Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages. Gizard F, Heywood EB, Findeisen HM, Zhao Y, Jones KL, Cudejko C, Post GR, Staels B, Bruemmer D. Arterioscler Thromb Vasc Biol. 2010 Nov 24. PubMed PMID: 21106948.

Telomerase Deficiency in Bone Marrow-Derived Cells Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation. Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D. Arterioscler Thromb Vasc Biol. 2010 Nov 18. PubMed PMID: 21088250.

Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.  Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS. Int J Biochem Cell Biol. 2010 June 22. PubMed PMID: 20184965.

T-Lymphocyte Responses to Intestinally Absorbed Antigens Can Contribute to Adipose Tissue Inflammation and Glucose Intolerance during High Fat Feeding. Wang Y, Li J, Tang L, Wang Y, Charnigo R, de Villiers W, Eckhardt E. PLoS One. 2010 Nov 11;5(11):e13951. PubMed PMID: 21085605.

Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}. Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A. Circ Res. 2010 Oct 15;107(8):953-8. PubMed PMID: 20798360; PubMed Central PMCID: PMC2963621.

Clinical efficacy and patient satisfaction with U-500 insulin use. Dailey AM, Williams S, Taneja D, Tannock LR. Diabetes Res Clin Pract. 2010 Jun;88(3):259-64. Epub 2010 Mar 11. PubMed PMID: 20226557.

Accumulation and expression of serum amyloid P component in human atherosclerotic lesions. Song Z, Cai L, Guo L, Tsukamoto Y, Yutani C, Li XA. Atherosclerosis. 2010 Jul;211(1):90-5. PMID: 20189569

Group X Secretory Phospholipase A2 Negatively Regulates ABCA1 and ABCG1 Expression and Cholesterol Efflux in Macrophages.  Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Arterioscler Thromb Vasc Biol. 2010 Jul 1. PubMed PMID: 20844270.

Transforming Growth Factor Beta Regulation of Proteoglycan Synthesis in Vascular Smooth Muscle: Contribution to Lipid Binding and Accelerated Atherosclerosis in Diabetes.  Yang SN, Burch ML, Tannock LR, Evanko S, Osman N, Little PJ. Epub. 2010 Jul 1. PubMed PMID: 20923499.

Genetic Variants of the Renin Angiotensin System: Effects on Atherosclerosis in Experimental Models and Humans. Daugherty A, Poduri A, Chen X, Lu H, Cassis LA. Curr Atheroscler Rep. 2010 May 12. PubMed PMID: 20425255.

Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy.  Campbell CL, Steinhubl SR, Hooper WC, Jozic J, Smyth SS, Bernstein D, De Staercke C, Syros G, Negus BH, Stuckey T, Stone GW, Mehran R, Dangas G. J Thromb Thrombolysis. 2010 Sep 25. PubMed PMID: 20872045.

Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.  Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D. Circ Res. 2010 Aug 20. PubMed PMID: 20558821.

Group X Secretory Phospholipase A2 Negatively Regulates ABCA1 and ABCG1 Expression and Cholesterol Efflux in Macrophages.   Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR. Group. Arterioscler Thromb Vasc Biol. 2010 Oct 30. PubMed PMID: 20844270.

Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.   Zack M, Boyanovsky BB, Shridas P, Bailey W, Forrest K, Howatt DA, Gelb MH, de Beer FC, Daugherty A, Webb NR. Atherosclerosis. 2010 Aug 19. PubMed PMID: 20833395.

Pioglitazone-Induced Reductions in Atherosclerosis Occur via Smooth Muscle Cell-Specific Interaction With PPAR {gamma}.   Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A. Circ Res. 2010 August 26.  PubMed PMID: 20798360.

Evidence of Mobilization of Pluripotent Stem Cells into Peripheral Blood of Patients with Myocardial Ischemia.   Abdel-Latif A, Zuba-Surma EK, Ziada KM, Kucia M, Cohen DA, Kaplan AM, Van Zant G, Selim S, Smyth SS, Ratajczak MZ. Exp Hematol. 2010 August 25.  PubMed PMID: 20800644.

Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands.   Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR.J Biol Chem. 2010 Jun 25;285(26):20031-9. PubMed PMID: 20421306; PubMed Central PMCID: PMC2888415.

NR4A Orphan Nuclear Receptors: Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology.   Zhao Y, Bruemmer D. Arterioscler Thromb Vasc. 2010 Aug 30. PubMed PMID: 20631354.

In memoriam: Stewart Charles Whitman (1964-2010).   Marcel Y, McBride H, Milne RW, Huff M, Daugherty A. J Lipid Res. 2010 Aug 10. PubMed PMID: 20699422.

Dietary Coenzyme Q10 Does Not Protect Against Cigarette Smoke-Augmented Atherosclerosis in apoE-deficient Mice.   Daugherty A. Radic Biol Med. 2010 June 1. PubMed PMID: 20227489.

A Phosphatidic Acid Binding/Nuclear Localization Motif Determines Lipin1 Function in Lipid Metabolism and Adipogenesis.   Smyth SS, Morris AJ. Mol Biol Cell. 2010 July 21. PubMed PMID: 20660155.

Impact of Serum Amyloid A on High Density Lipoprotein Composition and Levels.   J. Lipid Res. DeBeer MC, Van Der Westhuyzen D, DeBeer F, Webb NR. 2010 July 27. PubMed PMID: 20667817.

G-independent mechanism mediating Akt phosphorylation in platelets.   Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z. A. J Thromb Haemost. 2010 Jun 24. PubMed PMID: 20586915.

Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.   Li X, Shridas P, Forrest K, Bailey W, Webb NR. FASEB J. 2010 Jun 28. PubMed PMID: 20585029.

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.   Daugherty A, Rateri DL, Charo IF, Owens AP, Howatt DA, Cassis LA. Clin Sci (Lond). 2010 Mar 9;118(11):681-9. PubMed Central PMCID: PMC2841499.

Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.  Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach M, Choi YJ, Hennig B, Toborek M. J Neurosci Res. 2010 Jun 16. PMID: 20564349

Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis.  Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D. Circ Res. 2010 Jun 17. PMID: 20558821

Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.  Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Epub 2010 Jan 28. PMID: 20110354

High-density lipoprotein and the acute phase response.   Jahangiri A. Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):156-60. Review. PMID: 20177380

Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines.     Boyanovsky BB, Li X, Shridas P, Sunkara M, Morris AJ, Webb NR. Cytokine. 2010 Apr;50(1):50-7. Epub 2010 Feb 6.  PMID: 20138782

Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism.  Dong A, Caicedo J, Han SG, Mueller P, Saha S, Smyth SS, Gairola CG.  Thromb Res. 2010 May 6.  PMID: 20451958

Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenals.  Shridas P, Bailey WM, Boyanovsky BB, Oslund RC, Gelb MH, Webb NR.  J Biol Chem. 2010 Apr 26.  PMID: 20421306

Genetic variants of the Renin Angiotensin system: effects on athersclerosis in experimental models and humans.  Daugherty A, Poduri A, Chen X, Lu H, Cassis LA.  Durr Atheroscler Rep. 2010 May;12(3):167-73.  PMID: 20425255

Intensive glycemic control and cardiovascular disease: an update.  Brown A, Reynolds LR, Bruemmer D.  Nat Rev Cardiol. 2010 Apr 20.  PMID 20404853
Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Uchida HA, Kristo F, Rateri DL, Lu H, Charnigo R, Cassis LA, Daugherty A.  Atherosclerosis. 2010 Mar 4.  PMID: 20362292

Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals. Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z. J Biol Chem. 2010 Mar 19;285(12):8628-38. Epub 2010 Jan 19.  PMID: 20086008

A murine model of obesity with accelerated atherosclerosis. King VL, Hatch NW, Chan HW, de Beer MC, de Beer FC, Tannock LR.  Obesity (Silver Spring.  2010 Jan.; 18(1):35-41 Epub 2009 Jun 4.  PMID: 19498343

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.  Owens AP 3rd, Subramanian V, Moorleghen JJ, Guo Z, McNamara CA, Cassis LA, Daugherty A.  Circ Res 2010 Feb 19; 109(3):611-9. Epub 2009 Dec 17.  PMID: 20019328

Chylomicrons promote intestinal absorbtion and systemic dissemination of dietary antigen (ovalbumin) in mice.  Wang Y, Ghoshal S, Ward M, de Villiers W, Woodward J, Eckhardt E.  PLoS One.  2009 Dec 24.  PMID 20041190

The evolution of a department of internal medicine under an integrated clinical enterprise model: the University of Kentucky experience.  Means RT Jr, Moliterno DJ, Allison GR, Perman JA, Lofgren RP, Karpf M, Debeer FC.  Acad Med.  2010 Mar.  PMID 20182134

Clinical efficacy and patient satisfaction with U-500 insulin use.  Dailey AM, William S, Taneja D, Tannock LR.  Diabetes Res Clin Pract.  2010 Mar 10.  PMID 20226557


Dietary coenzyme Q10 does not protect against cigarette smoke-augmented athersclerosis in ApoE-deficient mice.  Gairola CG, Howatt DA, Daugherty A.  Free Radic Biol Med.  2010 Mar 11.  PMID 20227489

PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.  Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.  Mol Cell Biol.  2010 Mar 15.  PMID 20231358

Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms.  Police SB, Putnam K, Thatcher SE, Batifoulier-Yiannikouris F, Daugherty A, Cassis LA.  Am J Physiol Circ Physiol.  2010 Mar 19.  PMID 20304811

PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.  Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.  Mol Cell Biol.  2010 Mar 15.  PMID 20231358

Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms.  Police SB, Putnam K, Thatcher SE, Batifoulier-Yiannikouris F, Daugherty A, Cassis LA.  Am J Physiol Circ Physiol.  2010 Mar 19.  PMID 20304811

Platelet functions beyond hemostasis. Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC; 2009 Platelet Colloquium Participants.  J Thromb Haemost. 2009 Nov; 7(11): 1759-66. Epub 2009 Aug 19. Review. PMID 19691483

Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS. Int J Biochem Cell Biol. 2010 Feb 22.  PMID: 20184965

The Evolution of a Department of Internal Medicine Under an In tegrated Clinical Enterprise Model: The University of Kentucky Experience. Means RT Jr, Moliterno DJ, Allison GR, Perman JA, Lofgren RP, Karpf M, Debeer FC. Acad Med. 2010 Mar;85(3):531-537. PMID: 20182134

High-density lipoprotein and the acute phase response. Jahangiri A. Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):156-60. PMID: 20177380

Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. Brown A, Desai M, Taneja D, Tannock LR. Postgrad Med. 2010 Jan;122(1):163-71. Review. PMID: 20107300

Bioactive products generated by Group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines. Boyanovsky BB, Li X, Shridas P, Sunkara M, Morris AJ, Webb NR. Cytokine. 2010 Feb 5. PMID: 20138782

Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice. Taneja D, Thompson JC, Wilson PG, Brandewie K, Schaefer L, Mitchell B, Tannock LR.  2010 Jan 28. PMID: 20110440

Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. Miriyala S, Subbramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielman HP, Morris AJ. 2010 Jan 28. PMID: 20110354

Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. A, Desai M, Taneja D, Tannock LR. 2010 Jan; PMID: 20107300

Role of calcium-independent phospholipase A2{beta} in high glucose-induced activation of RhoA, Rho-kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals. Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z. J Biol Chem. 2010 Jan 19.  PMID: 20086008

Modes of defining atherosclerosis in mouse models: relative merits and evolving standards. Daugherty A, Lu H, Howatt DA, Rateri DL. Methods Mol Biol. 2009;573:1-15. Review. PMID: 19763919

Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in mice. Wang Y, Ghoshal S, Ward M, de Villiers W, Woodward J, Eckhardt E. PLoS One. 2009 Dec 24;4(12):e8442. PMID: 20041190

Atherosclerosis: cell biology and lipoproteins. Lu H, Daugherty A. Arterioscler Thromb Curr Opin Lipidol. 2009 Dec;20(6):528-9. PMID: 19935204

Blood Relatives: Dynamic Regulation of Bioactive Lysophosphatidic Acid and Sphingosine-1-Phosphate Metabolism in the Circulation. Morris AJ, Selim S, Salous A, Smyth SS. Trends Cardiovasc Med. 2009 May;19(4):135-140. PMID: 19818950

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Police SB, Thatcher SE, Charnigo R, Daugherty A, Cassis LA. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1458-64. Epub 2009 Jul 16. PMID: 19608970

Augmentation of the renin-angiotensin system by hypercholesterolemia promotes vascular diseases. Daugherty A, Lu H, Rateri DL, Cassis LA. Future Lipidol. 2008 Dec;3(6):625-636. PMID: 19802341

Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. Guo L, Song Z, Li M, Wu Q, Wang D, Feng H, Bernard P, Daugherty A, Huang B, Li XA. J Biol Chem. 2009 Jul 24;284(30):19826-34. Epub 2009 Jun 2. PMID: 19491399

Modes of defining atherosclerosis in mouse models: relative merits and evolving standards. Daugherty A, Lu H, Howatt DA, Rateri DL. Methods Mol Biol. 2009;573:1-15. PMID: 19763919


SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL. de Beer MC, Webb NR, Whitaker NL, Wroblewski JM, Jahangiri A, van der Westhuyzen DR, de Beer FC. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1298-303. Epub 2009 Mar 19. PMID: 19304574

Platelet functions beyond haemostasis. Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC; for the 2009 Platelet Colloquium Participants. J Thromb Haemost. 2009 Aug 19. [Epub ahead of print] PMID: 19691483

Periostin mediates vascular smooth muscle cell migration through the integrins alphanubeta3 and alphanubeta5 and focal adhesion kinase (FAK) pathway. Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN. Atherosclerosis. 2009 Jul 30. PMID: 19695571

Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. Guo L, Song Z, Li M, Wu Q, Wang D, Feng H, Bernard P, Daugherty A, Huang B, Li XA. J Biol Chem. 2009 Jul 24;284(30):19826-34. Epub 2009 Jun 2.PMID: 19491399

Thiol Oxidative Stress Induced by Metabolic Disorders Amplifies Macrophage Chemotactic Responses and Accelerates Atherogenesis and Kidney Injury in LDL Receptor-Deficient Mice. Qiao M, Zhao Q, Fung Lee C, Tannock LR, Smart EJ, Lebaron RG, Phelix CF, Rangel Y, Asmis R. Arterioscler Thromb Vasc Biol. 2009 Jul 10. PMID: 19592463

A Murine Model of Obesity With Accelerated Atherosclerosis. King VL, Hatch NW, Chan HW, de Beer MC, de Beer FC, Tannock LR. Obesity (Silver Spring). 2010 Jan;18(1):35-41. Epub 2009 Jun 4. PMID: 19498343

Measuring blood pressure in mice using volume pressure recording, a tail-cuff method. Daugherty A, Rateri D, Hong L, Balakrishnana A. J Vis Exp. 2009 May 15; (27). pii: 1291. doi: 10.3791/1291. PMID: 19488026

Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL. Boyanovsky BB, Shridas P, Simons M, van der Westhuyzen DR, Webb NR. J Lipid Res. 2009 Apr;50(4):641-50. Epub 2008 Dec 3. PMID: 19056705. PMCID: PMC2656657

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, Wei J, Daugherty A, Smart EJ, Reid MB, Merrill AH Jr, Nikolova-Karakashian M. J Biol Chem. 2009 Mar 27;284(13):8359-68. Epub 2008 Dec 11. PMID: 19074137

Atherosclerosis: cell biology and lipoproteins. Daugherty A, Lu H, Rateri DL. Curr Opin Lipidol. 2009 Jun;20(3):260-1. PMID: 19433924
ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Cassis LA, Gupte M, Thayer S, Zhang X, Charnigo R, Howatt DA, Rateri DL, Daugherty A. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1660-5. Epub 2009 Feb 27 PMID: 19252100

Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel. Oestreich JH, Holt J, Dunn SP, Smyth SS, Campbell CL, Charnigo R, Akers WS, Steinhubl SRArterioscler Thromb Vasc Biol. 2009 Apr;29(4):449-57. Epub 2008 Nov 20. Coron Artery Dis. 2009 May;20(3):207-13. PMID: 19318928

G-protein-coupled receptors as signaling targets for antiplatelet therapy. Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC; 2008 Platelet Colloquium Participants. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):449-57. Epub 2008 Nov 20. PMID: 19023091 Chylomicrons promote intestinal absorption of lipopolysaccharides. Ghoshal S, Witta J, Zhong J, de Villiers W, Eckhardt E. J Lipid Res. 2009 Jan;50(1):90-7. Epub 2008 Sep 24. PMID: 18815435

The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivp. Boyanovsky B, Zack M, Forrest K, Webb NR. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):532-8. Epub 2009 Jan 22. PMID: 19164803

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice. Deevska GM, Rozenova KA, Giltiay NV, Chambers MA, White J, Boyanovsky BB, Wei J, Daugherty A, Smart EJ, Reid MB, Merrill AH Jr, Nikolova-Karakashian M. J Biol Chem. 2009 Mar 27;284(13):8359-68. Epub 2008 Dec 11. PMID: 19074137

Thrombosis and antithrombotic therapy in women. Bailey AL, Scantlebury DC, Smyth SS. Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):284-8. Epub 2009 Feb 16. Review. PMID: 19221205

HDL remodeling during the acute phase response. Jahangiri A, de Beer MC, Noffsinger V, Tannock LR, Ramaiah C, Webb NR, van der Westhuyzen DR, de Beer FC. Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):261-7. Epub 2008 Nov 13. PMID: 19008529

Biology of secretory phospholipase A2. Boyanovsky BB, Webb NR. Cardiovasc Drugs Ther. 2009 Feb;23(1):61-72. Epub 2008 Oct 14. Review. PMID: 18853244

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. King VL, Lin AY, Kristo F, Anderson TJ, Ahluwalia N, Hardy GJ, Owens AP 3rd, Howatt DA, Shen D, Tager AM, Luster AD, Daugherty A, Gerszten RE. Circulation. 2009 Jan 27;119(3):426-35. Epub 2009 Jan 12. PMID: 19139386

Deficiency of the NR4A Neuron-Derived Orphan Receptor-1 Attenuates Neointima Formation After Vascular Injury.  Takashi Nomiyama, MD, PhD; Yue Zhao, MS; Florence Gizard, PhD; Hannes M. Findeisen, MD; Elizabeth B. Heywood, MS; Karrie L. Jones, BS; Orla M. Conneely, PhD; Dennis Bruemmer, MD. Received March 13, 2008; accepted November 19, 2008.

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