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You are located on L. Kesavalu, B.V.Sc., M.Sc., S.C.C. webpage.

L. Kesavalu, B.V.Sc., M.Sc., S.C.C.

Photo of L. Kesavalu, B.V.Sc., M.Sc., S.C.C.
knlaks0@email.uky.edu

Associate Professor - Research
B.V.Sc Degree in Veterinary Medicine and Surgery,
Madras Veterinary College, Madras University, India 

S.C.C Senior Certificate Course - Advanced Statistical Training
Institute of Agricultural Research Statistics, New Delhi, India

M.Sc Masters Degree in Medical Microbiology,
All India Institute of Medical Sciences, New Delhi, India

Research

Research interests to study the role of oral bacteria in the progression of periodontitis, gene expression, and host-response induction. We use rat and mouse models (Periodontal disease model, calvarial bone resorption model) to examine specific bacterial molecular pathogenesis such as monobacterial periodontal disease, polymicrobial periodontal disease, polymicrobial synergism, microbial succession, periodontal disease markers, and global gene expression to periodontal pathogens Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola.

Currently there are four funded projects:
1. Studying the role of dietary n-3 polyunsaturated fatty acid (PUFA) regulation on molecular host responses to oral infection with P. gingivalis in rat periodontitis model [R21 NIH/NIDCR/Office of Dietary Supplements: n-3 Fatty Acid & Host Responses to Oral Infection].

2. Examining mono- and polymicrobial virulence interactions and global gene expression in mouse calvarial model [RO1 NIH/NIDCR Oral Pathogens: Polymicrobial Virulence Interactions].

3. Developing mono- and polymicrobial periodontal infection models in rats to P. gingivalis, T. denticola, and T. forsythia in periodontal disease [NCRR-COBRE Transition Support Award], and

4. Examining extracorporeal shock Multi wave therapy (ESWT) regeneration of alveolar bone loss post P. gingivalis infection in rat periodontitis model [Bioden Technologies & Tissue Regeneration Technologies].

Publications

(i) Holt, S. C., L. Kesavalu, S. G. Walker, C. A. Genco. 1999. Virulence factors of Porphyromonas gingivalis. In: Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease. Ed: Jorgan Slots. Periodontology 2000. 20: 168-239. REVIEW ARTICLE.

(ii) Kesavalu, L., S. C. Holt, and J. L. Ebersole. 1999. Lack of humoral immune protection against Treponema denticola virulence in a murine model. Infect. Immun. 67: 5736-5746.

(iii) Ebersole, J. L., D. Cappelli, G. Mott, L. Kesavalu, S. C. Holt, R. E. Singer. 1999. Systemic manifestations of periodontitis in nonhuman primate. J. Periodont. Res. 34:358-362.

(iv) Kesavalu, L., C. W. Falk, K. J. Davis, M. J. Steffen, X. Xu, S. C. Holt, and J. L. Ebersole. 2002. Biological characterization of lipopolisaccharide from Treponema pectinovorum. Infect. Immun. 70:211-217.

(v) Kesavalu, L., B. Chandrasekar, and J. L. Ebersole. 2002. In vivo induction of proinflammatory cytokine in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral. Microbiol. Immunol. 17:177-180.

(vi) Kesavalu, L., S. C. Holt and J. L. Ebersole. 2003. In vitro environmental regulation of Porphyromonas gingivalis growth and virulence. Oral. Microbiol. Immunol. 18:226-233.

(vii) Jeffrey L. Ebersole, Archana Meka, Arnold Stromberg, Chris Saunders, and Lakshmyya Kesavalu. 2005. Host Gene Expression in Local Tissues in Response to Periodontal Pathogens. Oral Biosciences & Medicine. 2 (2/3): 175-184.

(viii) Kesavalu, L., B. Vasudevan, B. Raghu, E. Browning, D. Dawson , M. J. Novak, M. C. Correll, M. Steffen, A. Bhattacharya, G. Fernandes, and J. L. Ebersole. 2005. n-3 Polyunsaturated Fatty Acid Effect on Alveolar Bone Loss in Rats. Journal Dental Research.

Contact Info

University of Kentucky
Chandler Medical Center
159 Health Science Research Building
College of Dentistry
800 Rose Street

Lexington, Kentucky 40536-0305

Tel: (859) 323-0045
Fax: (859) 257-6566

Email: knlaks0@email.uky.edu

 

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