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Research
interests to study the role of oral bacteria in the
progression of periodontitis, gene expression, and
host-response induction. We use rat and mouse models
(Periodontal disease model, calvarial bone resorption
model) to examine specific bacterial molecular
pathogenesis such as monobacterial periodontal disease,
polymicrobial periodontal disease, polymicrobial
synergism, microbial succession, periodontal disease
markers, and global gene expression to periodontal
pathogens Porphyromonas gingivalis, Tannerella
forsythia, and Treponema denticola.
Currently there are four funded
projects:
1. Studying the role of dietary n-3 polyunsaturated fatty
acid (PUFA) regulation on molecular host responses to oral
infection with P. gingivalis in rat periodontitis
model [R21 NIH/NIDCR/Office of Dietary Supplements: n-3
Fatty Acid & Host Responses to Oral Infection].
2. Examining mono- and polymicrobial virulence
interactions and global gene expression in mouse calvarial
model [RO1 NIH/NIDCR – Oral Pathogens: Polymicrobial
Virulence Interactions].
3. Developing mono- and polymicrobial periodontal
infection models in rats to P. gingivalis, T. denticola,
and T. forsythia in periodontal disease [NCRR-COBRE
Transition Support Award], and
4. Examining extracorporeal shock Multi wave therapy (ESWT)
regeneration of alveolar bone loss post P. gingivalis
infection in rat periodontitis model [Bioden
Technologies & Tissue Regeneration Technologies].
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(i) Holt,
S. C., L. Kesavalu, S. G. Walker, C. A. Genco. 1999.
Virulence factors of Porphyromonas gingivalis. In:
Actinobacillus actinomycetemcomitans and Porphyromonas
gingivalis in periodontal disease. Ed: Jorgan Slots.
Periodontology 2000. 20: 168-239. REVIEW ARTICLE.
(ii) Kesavalu, L., S. C. Holt, and J. L. Ebersole. 1999.
Lack of humoral immune protection against Treponema
denticola virulence in a murine model. Infect. Immun.
67: 5736-5746.
(iii) Ebersole, J. L., D. Cappelli, G. Mott, L. Kesavalu,
S. C. Holt, R. E. Singer. 1999. Systemic manifestations of
periodontitis in nonhuman primate. J. Periodont. Res.
34:358-362.
(iv) Kesavalu, L., C. W. Falk, K. J. Davis, M. J. Steffen,
X. Xu, S. C. Holt, and J. L. Ebersole. 2002. Biological
characterization of lipopolisaccharide from Treponema
pectinovorum. Infect. Immun. 70:211-217.
(v) Kesavalu, L., B. Chandrasekar, and J. L. Ebersole.
2002. In vivo induction of proinflammatory cytokine in
mouse tissue by Porphyromonas gingivalis and
Actinobacillus actinomycetemcomitans. Oral. Microbiol.
Immunol. 17:177-180.
(vi) Kesavalu, L., S. C. Holt and J. L. Ebersole. 2003. In
vitro environmental regulation of Porphyromonas gingivalis
growth and virulence. Oral. Microbiol. Immunol.
18:226-233.
(vii) Jeffrey L. Ebersole, Archana Meka, Arnold Stromberg,
Chris Saunders, and Lakshmyya Kesavalu. 2005. Host Gene
Expression in Local Tissues in Response to Periodontal
Pathogens. Oral Biosciences & Medicine. 2 (2/3): 175-184.
(viii) Kesavalu, L., B. Vasudevan, B. Raghu, E. Browning,
D. Dawson , M. J. Novak, M. C. Correll, M. Steffen, A.
Bhattacharya, G. Fernandes, and J. L. Ebersole. 2005. n-3
Polyunsaturated Fatty Acid Effect on Alveolar Bone Loss in
Rats. Journal Dental Research.
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Associate Professor - Research
