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You are located on John Novak, Ph.D., M.S., LDS, BDS webpage.

John Novak, Ph.D., M.S., LDS, BDS

Photo of John Novak, Ph.D., M.S., LDS, BDS
mjnova2@uky.edu

Professor of Periodontics
Associate Director, Center for Oral Health Research 
BDS, Guys Hospital, University of London, England 
LDS, RCS. Royal College of Surgeons, England 
M.S., University of Rochester, Rochester, NY 
Ph.D., University of Rochester, Rochester, NY 
Specialty Certification in Periodontics, Eastman Dental Center, Rochester, NY 
Diplomate, American Board of Periodontology 
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Research

Our overall focus is studying the oral cavity as a source of infection and inflammation that may have an impact on other areas of the body, other medical conditions, and the aging process. In addition, we are developing new ways of treating oral infection and inflammation that may be more cost effective than traditional surgical therapy and, for some patients, more long lasting.

Current areas of interest include: 

The effects of periodontal therapy on pre-term birth (University of Kentucky PI, NIH/NIDCR multicenter study) 

The effects of aging on oral infection, inflammation and disease (PI, NIH/NIA study) 

The use of host modulation in the treatment of periodontal disease [PI, FDA Phase IV multicenter study for the use of
     subantimicrobial doxycycline (Periostat; CollaGenex Pharmaceuticals) combined with Atrisorb and scaling and root planing in
     the treatment of periodontal disease]

The use of host modulation in the treatment of periodontal disease [PI, FDA Phase III multicenter study for the use of single
    daily dose of subantimicrobial doxycycline (Periostat; CollaGenex Pharmaceuticals) combined with scaling and root planing in 
    the treatment of periodontal disease]

Publications

Yan, SR, and MJ Novak: Src -family Kinase p53/56lyn Plays an Important Role in TNFa-Stimulated Production of O2- by 
Human Neutrophils Adherent to Fibrinogen.. Inflammation 23: 2; 167-178, 1999

Yan, SR, and MJ Novak. B2 Integrin-dependent phosphorylation of tyrosine kinase Pyk2 stimulated by TNFa and fMLP in 
human neutrophils adherent to fibrinogen. FEBS LETT 451: 33-38, 1999

Yan, SR and MJ Novak. Diverse Effects of Neutrophil Integrin Occupation on Respiratory Burst Activation. Cellular Immunol 
195:119-126, 1999

Novak, MJ. Necrotizing Ulcerative Periodontitis. In: Proceedings of the 1999 World Workshop in Periodontics. Annals of 
Periodontol 4:74-77, 2000.

Novak, MJ, LP Johns, RC Miller, and MH Bradshaw. Adjunctive benefits of subantimicrobial dose doxycycline in the 
management of severe, generalized, chronic periodontitis. J Periodontol 73:762-769, 2002 

Novak, MJ, and TG Donley. Advances in dentistry: Using host response modifiers in the treatment of periodontal disease. 
Practical Procedures & Aesthetic Dentistry 14:(suppl), 3-10,2002.

Ebersole JL, D Capelli, EC Mathys, MJ Steffen, RE Singer, M Montgomery, GE Mott, and MJ Novak. Periodontitis in humans
and nonhuman primates: oral systemic linkage inducing acute phase proteins.Ann Periodontol 7:102-111, 2002

Preshaw, PM, AF Hefti, MJ Novak, BS Michalowicz, BL Pihlstrom, R Schoor, CL Trummel, TE Van Dyke, CB Walker, MH
Bradshaw. Subantimicrobial dose doxycycline enhances efficacy of scaling and root planing in chronic periodontitis. J Periodontol
(accepted for publication) 2004

Contact Info

Dr. M. John Novak 
Professor and Associate Director 
Center for Oral Health Research 
University of Kentucky 
414 Health Sciences Research Building
Room 401
1095 V.A. Drive
Lexington, KY 40536-0305

Tel: (859) 323-5159 
Fax:(859) 257-6566 

Email: mjnova2@uky.edu

 

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