jleber2@uky.edu

Our laboratory's emphasis is the determination of host responses associated with bacterial colonization/infection by selected periodontopathic bacteria. Our emphasis with respect to these polymicrobial infections and responses to biofilms have been: (1) to characterize the use of a murine model for studies delineating the bacterial and host components that contribute to both soft and hard tissue destruction caused by these pathogens; (2) to utilize the nonhuman primate model of periodontitis to evaluate host-bacterial interactions in the chronic inflammatory disease; (3) to delineate the macromolecules of these bacteria that elicit the production/secretion of various host inflammatory mediators from non-immune cells (ie. gingival fibroblasts, epithelial cells); and, (4) to provide translational evidence on biologic links between oral infections and systemic diseases.

Moritz A, D Cappelli, M Lantz, SC Holt, and JL Ebersole. 1998. Immunization with P. gingivalis cysteine protease: Effects on gingivitis and ligament induced periodontitis in M. fascicularis. J Periodontol. 69:686-697. 

Çelénligil H and JL Ebersole. 1999. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet's Disease. J. Periodontol., 70:1449-1456. 

Ebersole JL, D Cappelli, G Mott, L Kesavalu, SC Holt, and RE Singer. 1999. Systemic manifestations of periodontitis in the non-human primate. J. Periodont. Res. 34:358-362. 

Nixon CS, MJ Steffen, and JL Ebersole. 2000. Cytokine responses of human gingival fibroblasts to Treponema pectinovorum and Treponema denticola. Infect. Immun., 68:5284-5292. 

Kesavalu L, CW Falk, KJ Davis, MJ Steffen, X Xu, SC Holt, and JL Ebersole. 2002. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect. Immun. 70: 211-217. 

Kesavalu L, B Chandrasekar, and JL Ebersole. 2002. In vivo induction of proinflammatory cytokine in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral. Microbiol. Immunol., 17: 177-180. 

Chu L, X Xu, Z Dong, D Cappelli, and JL Ebersole. 2003. Role for recombinant gamma-glutamyltransferase from Treponema denticola in glutathione metabolism. Infect. Immun. 71:335-342. 

Ebersole JL. 2003. Humoral responses in gingival crevicular: Local and systemic implications. ed. J. Uitto, Periodontology 2000, 31:135-166.

Ebersole JL, D Cappelli, EC Mathys, MJ Steffen, RE Singer, M Montgomery, GE Mott, and MJ Novak. 2003. Periodontitis in humans and nonhuman primates: Oral-systemic linkage inducing acute phase proteins. Ann. Periodontol. (in press).