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You are located on Jeffrey L. Ebersole, Ph.D. webpage.

Jeffrey L. Ebersole, Ph.D.

Photo of Jeffrey L. Ebersole, Ph.D. - The Director for The Center For Oral Health Research
jleber2@uky.edu

Alvin L. Morris Professor of Oral Health Research
Director, Center for Oral Health Research
Associate Dean for Research
B.S., Biology, Temple University
Ph.D., Microbiology, University of Pittsburgh
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Research

Our laboratory's emphasis is the determination of host responses associated with bacterial colonization/infection by selected periodontopathic bacteria. Our emphasis with respect to these polymicrobial infections and responses to biofilms have been: (1) to characterize the use of a murine model for studies delineating the bacterial and host components that contribute to both soft and hard tissue destruction caused by these pathogens; (2) to utilize the nonhuman primate model of periodontitis to evaluate host-bacterial interactions in the chronic inflammatory disease; (3) to delineate the macromolecules of these bacteria that elicit the production/secretion of various host inflammatory mediators from non-immune cells (ie. gingival fibroblasts, epithelial cells); and, (4) to provide translational evidence on biologic links between oral infections and systemic diseases.

Publications

Moritz A, D Cappelli, M Lantz, SC Holt, and JL Ebersole. 1998. Immunization with P. gingivalis cysteine protease: Effects on gingivitis and ligament induced periodontitis in M. fascicularis. J Periodontol. 69:686-697. 

Çelénligil H and JL Ebersole. 1999. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet's Disease. J. Periodontol., 70:1449-1456. 

Ebersole JL, D Cappelli, G Mott, L Kesavalu, SC Holt, and RE Singer. 1999. Systemic manifestations of periodontitis in the non-human primate. J. Periodont. Res. 34:358-362. 

Nixon CS, MJ Steffen, and JL Ebersole. 2000. Cytokine responses of human gingival fibroblasts to Treponema pectinovorum and Treponema denticola. Infect. Immun., 68:5284-5292. 

Kesavalu L, CW Falk, KJ Davis, MJ Steffen, X Xu, SC Holt, and JL Ebersole. 2002. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect. Immun. 70: 211-217. 

Kesavalu L, B Chandrasekar, and JL Ebersole. 2002. In vivo induction of proinflammatory cytokine in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral. Microbiol. Immunol., 17: 177-180. 

Chu L, X Xu, Z Dong, D Cappelli, and JL Ebersole. 2003. Role for recombinant gamma-glutamyltransferase from Treponema denticola in glutathione metabolism. Infect. Immun. 71:335-342. 

Ebersole JL. 2003. Humoral responses in gingival crevicular: Local and systemic implications. ed. J. Uitto, Periodontology 2000, 31:135-166.

Ebersole JL, D Cappelli, EC Mathys, MJ Steffen, RE Singer, M Montgomery, GE Mott, and MJ Novak. 2003. Periodontitis in humans and nonhuman primates: Oral-systemic linkage inducing acute phase proteins. Ann. Periodontol. (in press).

Contact Info

Dr. Jeff Ebersole
University of Kentucky
414 Health Sciences Research Building
1095 V.A. Drive
Room 422
Lexington, KY 40536-0305

Tel: (859) 323-5357 
Fax: (859) 257-6566 

Email: jleber2@uky.edu

Other web pages:  http://www.mc.uky.edu/Dentistry/

 

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