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Deneys
Van Der Westhuyzen
Professor
B.Sc.(Hons) (Biochemistry),University
of the Witwatersrand
Ph.D. (Biochemistry), University of Cape Town
dvwest1@pop.uky.edu
(859)
233-4511x4580
Research Interests |
Publications |
PubMed
Research
Interests:
Research
in my laboratory is focused on lipoprotein receptors and how such receptors
contribute to or protect against atherosclerosis. Oxidized and modified
lipoproteins play a key role in the development of atherosclerosis and our
laboratory is studying various scavenger receptors that mediate the metabolism
of such lipoprotein particles. One such receptor, the scavenger receptor-BI
(SR-BI), is also a newly described receptor for HDL. SR-BI mediates the
selective delivery of HDL cholesterol ester to cells and is a candidate receptor
for mediating "reverse cholesterol transport" from extrahepatic
tissues to the liver. We have shown that SR-BI exists as alternatively-spliced
variants and we are currently studying the significance and biological functions
of these receptor isoforms. This includes an investigation of the regulation of
expression of SR-BI isoforms in different tissues and the regulation by
cholesterol and oxidized lipids. The
effect of dietary cholesterol and high fat "Western Diet" on the
expression of scavenger receptors is also being studied. A central hypothesis
being examined is that modification of HDL during inflammation leads to
alterations in the interaction between HDL and SR-BI. Inflammation, as occurs in
the atherosclerotic lesion, includes a wide variety of metabolic changes
including a major modulation of HDL structure. Such changes would have important
implications for HDL metabolism and could affect HDL-mediated cholesterol
delivery to the liver, as well as cholesterol flux between HDL and cells in
localized atherosclerotic lesions and the accumulation of cholesterol in the
artery wall.
Representative Publications:
| 5: |
Pagler TA, Rhode S, Neuhofer A, Laggner H, Strobl W, Hinterndorfer
C, Volf I, Pavelka M, Eckhardt ER, van der Westhuyzen DR, Schutz GJ,
Stangl H. |
Related Articles,
Links |
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SR-BI-mediated high
density lipoprotein (HDL) endocytosis leads to HDL resecretion
facilitating cholesterol efflux.
J
Biol Chem. 2006 Apr 21;281(16):11193-204. Epub 2006 Feb 16.
PMID: 16488891 [PubMed - indexed for MEDLINE] |
| 9: |
Boyanovsky BB, van der Westhuyzen DR, Webb NR. |
Related Articles,
Links |
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Group V secretory
phospholipase A2-modified low density lipoprotein promotes foam cell
formation by a SR-A- and CD36-independent process that involves
cellular proteoglycans.
J
Biol Chem. 2005 Sep 23;280(38):32746-52. Epub 2005 Jul 21.
PMID: 16040605 [PubMed - indexed for MEDLINE] |
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